Detail of "13123-07-4"

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DNA damage induced in human diploid cells by decay of incorporated radionuclides

DNA damage induced in human diploid cells by decay of incorporated radionuclides. LeMotte, Peter K.; Little, John B. (Lab. Radiobiol., Harvard Sch. 52497-68-4 and 13123-07-4 are cas registry numbers. These chemicals are also mentioned in this article. Public Health, Boston, MA 02115, USA). Cancer Res., 44(4), 1337-42 (English) 1984. CODEN: CNREA8. ISSN: 0008-5472. DOCUMENT TYPE: Journal CA Section: 8 (Radiation Biochemistry) Alk. and neutral elution techniques were used to characterize the prodn. of single- and double-strand DNA breaks in human diploid fibroblasts by incorporated radionuclides. 125I was incorporated in DNA as [125I]iododeoxyuridine, 3H as [3H]thymidine, and 14C as [14C]thymidine. Under frozen conditions, 125I was 3-fold as efficient as 3H per decay in inducing single-strand breaks and 6-fold as efficient as 14C. For double-strand break prodn., however, 125I was 6-fold as efficient per decay as 3H. It was calcd. that, on the av., each 125I decay produces ~1 double-strand break in the frozen state. Under nonfrozen conditions, 125I and external x-rays were roughly 5-fold and 3H ~3-fold more efficient in double-strand break induction than under frozen conditions. .