Detail of > 131707-25-0
- CAS Number:
- 131707-25-0
- Name:
Arbidol
- Formula:
- C22H25BrN2O3S
- Molecular Structure:
- Synonyms:
- Ethyl 6-bromo-5-hydroxy-1-methyl-4-((dimethylamino)methyl)-2-[(phenylthio)methyl]-1H-indole-3-carboxylate;ethyl 6-bromo-4-[(dimethylamino)methyl]-5-hydroxy-1-methyl-2-[(phenylsulfanyl)methyl]-1H-indole-3-carboxylate;
- Molecular Weight:
- 531.89
- Density:
- 1.375 g/cm3
- Boiling Point:
- 591.776 °C at 760 mmHg
- Flash Point:
- 311.695 °C
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Reference
- Preparation of ethyl 6-bromo-5-hydroxy-4-dimethylamino-1-methyl-2-(phenylthiomethyl)indol e-3-carboxylate hydrochloride monohydrate as an antiviral and interferon inducer
- Preparation of ethyl 6-bromo-5-hydroxy-4-dimethylamino-1-methyl-2-(phenylthiomethyl)indol e-3-carboxylate hydrochloride monohydrate as an antiviral and interferon inducer. Grinev, A. N.; Pershin, G. N.; Trofimov, F. A.; Tsyshkova, N. G.; Bogdanova, N. S.; Nikolaeva, I. S.; Zotova, S. A.There are some reagents with their cas registry numbers 131707-23-8 and 131707-25-0 are used in this study.; Sakhashchik, Z. M.; Svirina, E. A.; et al. (Ordzhonikidze, S., All-Union Scientific-Research Chemical-Pharmaceutical Institute; Scientific-Research Institute of Medical Radiology, Academy of Medical Sciences, U.S.S.R.; Leningrad Scientific-Research Institute of Epidemiology and Microbiology, USSR). Patentschrift (Switz.) CH 678726 A 31 Oct 1991, 16 pp. (Switzerland). CODEN: SWXXAS. CLASS: ICM: C07D209-18. ICS: A61K031-405. APPLICATION: CH 90-3071 12 Jan 1989. PRIORITY: WO 89-SU272 12 Jan 1989. DOCUMENT TYPE: Patent CA Section: 27 (Heterocyclic Compounds (One Hetero Atom)) Section cross-reference(s): 1 The title compd., prepd. in 4 steps from Et 5-acetoxy-1,2-dimethylindole-3-carboxylate, gave 640-1280 units/mL serum interferon after 24 h (control = 10-20 units/mL) in mice at 250 mg/kg orally. .
- 1-Methyl-2-(phenylthiomethyl)-3-(carbethoxy)-4-(dimethylaminomethyl)- 5-hydroxy-6-bromoindole hydrochloride having antiviral activity and method for preparing it
- 1-Methyl-2-(phenylthiomethyl)-3-(carbethoxy)-4-(dimethylaminomethyl)- 5-hydroxy-6-bromoindole hydrochloride having antiviral activity and method for preparing it. Grinev, A. N.; Trofimov, F. A.; Tsyshkova, N. G.; Pershin, G. N.; Bogdanova, N. S.; Nikolaeva, I. S. (Ordzhonikidze, S., All-Union Scientific-Research Chemical-Pharmaceutical Institute; Scientific-Research Institute of Medical Radiology, Academy of Medical Sciences, U.Some commonly used reagents like 131707-23-8 and 131707-25-0 are used in this experiment.S.S.R., USSR). U.S.S.R. SU 1685933 A1 23 Oct 1991 From: Otkrytiya, Izobret. 1991, (39), 96. (Union of Soviet Socialist Republics). CODEN: URXXAF. CLASS: ICM: C07D209-04. APPLICATION: SU 74-2078680 27 Nov 1974. DOCUMENT TYPE: Patent CA Section: 27 (Heterocyclic Compounds (One Hetero Atom)) Section cross-reference(s): 1 The title compd. (I) has antiviral activity. I is prepd. from 1,2-dimethyl-3-(carbethoxy)-5-acetoxy-6-bromoindole by: (1) bromination with NBS and H2O2 catalyst/initiator in CCl4; (2) reaction of the obtained 2-bromomethyl deriv. with PhSH and an alkali metal base to give the 2-(phenylthiomethyl) deriv.; (3) hydrolysis of the acetate group by aq. mineral acid in an org. solvent (esp. alc.-Me2CO); (4) reaction of the obtained 5-hydroxy deriv. with CH2(NMe2)2 in dioxane; and (5) salification by std. methods. .
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