Reference

Inclusion complexation of metronidazole benzoate with b-cyclodextrin and its depression of anhydrate-hydrate transition in aqueous suspensions

Inclusion complexation of metronidazole benzoate with b-cyclodextrin and its depression of anhydrate-hydrate transition in aqueous suspensions. Andersen, Finn M.; Bundgaard, Hans (Dep. Pharm. Chem., R. Dan. Sch. Pharm., Copenhagen DK-2100, Den.). Int. J. Pharm., 19(2), 189-97 (English) 1984. CODEN: IJPHDE. ISSN: 0378-5173. DOCUMENT TYPE: Journal CA Section: 63 (Pharmaceuticals) Section cross-reference(s): 22 Metronidazole benzoate (I) [13182-89-3] formed an inclusion complex with b-cyclodextrin (b-CyD) in aq. soln. and in the solid phase. A phase soly. diagram was obtained and an apparent 1:1 formation complex const. of 1.3 ′ 103 M-1 was detd. A microcryst. inclusion complex had the stoichiometric compn. of 1:1.5 (drug-b-CyD). By inclusion complexation of the I with b-CyD the phase transition of the clin. used anhyd. form of the compd. to the monohydrate, occurring in aq. suspensions, was inhibited as was the marked crystal growth resulting from the phase transition. Besides increasing the phys. stability of I suspensions, complexation with b-CyD protected the drug against photochem. degrdn. and decreased the rate of hydrolysis.

A new spectrophotometric method for the estimation of metronidazole and metronidazole benzoate

A new spectrophotometric method for the estimation of metronidazole and metronidazole benzoate. Chowdary, K. P. R.; Kumar, K. T. Raghu (Dep. Pharm. Sci., Andhra Univ., Waltair, India). Indian J. Pharm.In this article, certain chemicals are used. Some of their cas registry numbers are 13182-89-3 and 443-48-1 Sci., 45(4), 182-3 (English) 1983. CODEN: IJSIDW. ISSN: 0250-474X. DOCUMENT TYPE: Journal CA Section: 64 (Pharmaceutical Analysis) Metronidazole [443-48-1] is detd. in tablets and in suspensions contg. metronidazole benzoate [13182-89-3] by extn. with 10% HCO2H in iso-PrOH. The exts. were mixed with MeOH and 30% KOH and the color was measured at 370 nm after 1 h. Beer's law held for 0-4 mg/mL and the recovery was 97.4-101%. The relative error was <1%. .