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Detail of "13189-98-5"

  • CAS Number:
  • 13189-98-5
  • Name:
  • Fudosteine

  • Molecular Structure:
  • Formula:
  • C6H13NO3S
  • Molecular Weight:
  • 179.26
  • Synonyms:
  • SS 320A;S-(3-Hydroxypropyl)cysteine;(2R)-2-amino-3-(3-hydroxypropylsulfanyl)propanoic acid;Cleanal;Cleanal (TN);L-Cysteine, S-(3-hydroxypropyl)-;(-)-3-((3-Hydroxypropyl)thio)-L-alanine;Alanine, 3-((3-hydroxypropyl)thio)-, L- (8CI);Alanine, 3-((3-hydroxypropyl)thio)-, L-;S-(3-hydroxypropyl)-l-cysteine;L-Cysteine,S-(3-hydroxypropyl)-;
  • Density:
  • 1.301 g/cm3
  • Melting Point:
  • 200-202 °C (dec.)
  • Boiling Point:
  • 354.5 °C at 760 mmHg
  • Flash Point:
  • 168.2 °C
  • Appearance:
  • off-white powder

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CAS No.13189-98-5 FudosteineCompetitive Product

Assay:99%  Appearance:White OR off...  Package:25kg/drumStorage:Normal tempe...  Transportation:general

Supplier:Jinan Jianfeng Chemical Co., Ltd [ China (Mainland)]

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CAS No.13189-98-5 FudosteineCompetitive Product

13189-98-5 Fudosteine Synonyms (R)-2-Amino-3-(3-hydroxypropylthio)propionic acid Molecular Formula C6H13NO3S Molecular Weight 179.23 CAS Registry Number 13189-98-5

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CAS No.13189-98-5 Fudosteine

  Package:1Mg;5Mg;10Mg...Storage:store in RT  Transportation:by air/sea  Application:Fudosteine

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Assay:99%  Appearance:Almost white...

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Fudosteine

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CAS No.13189-98-5 Fudosteine

Fudosteine

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Fudosteine;

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CAS No.13189-98-5 Fudosteine

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CAS No.13189-98-5 Fudosteine

Assay:above 98%  Appearance:white or alm...  Package:25kg/fibre d...

product name:Fudosteine second name:(R)-2-Amino-3-(3-hydroxypropylthio)propionic CAS no:13189-98-5 Density: 1.301g/cm3 Boiling point :354.5°C at 760 mmHg Refractive index: 1.558 Flash point: 168.2°C Vapour Pressure :1.92E-06mmHg at 25°C mol str: mol fm:C6H13NO3S

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CAS No.13189-98-5 Fudosteine

Assay:99%  Appearance:off-white po...  Package:as you reque...

Fudosteine MF: C6H13NO3S

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CAS No.13189-98-5 Fudosteine

Name of Substance: fudosteine CAS Registry Number: 13189-98-5 Molecular Formula:C6-H13-N-O3-S Assay: >99.0% to 101.0% Packing :10kg/drum

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CAS No.13189-98-5 Fudosteine

Fudosteine is a novel mucoactive agent and a MUC5AC mucin hypersecretion inhibitor.

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Reference

Studies on the in vivo formation of acrolein
Studies on the in vivo formation of acrolein. 3-Hydroxypropylmercapturic acid as an index of cyclophosphamide (NSC-26271) activation. Alarcon, R. A. (Dep. Biol. Chem., Harvard Med. Sch., Boston, Mass., USA). Cancer Treat. Rep., 60(4), 327-35 (English) 1976. CODEN: CTRRDO. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) 3-Hydroxypropylmercapturic acid (MCA) was detd. in the urine of rats given cyclophosphamide (I), related antineoplastic agents, allyl alc., or acrolein. Male rats injected with I (50 mg/kg) excreted 16. 13189-98-5 and 616-91-1 are cas registry numbers. These chemicals are also mentioned in this article.7 .mu.mols of MCA/kg in their 24 h urine. Equiv. isophosphamide, triphosphamide, ASTA-5607, ASTA-5122, and cytoxyl alc. produced 9.0, 16.1, 4.1, and 0.4 .mu.mols MCA/kg, resp. After administration of allyl alc. and acrolein, 26.3 and 19.7 .mu.mols MCA/kg were obtained. MCA values were directly proportional to the drug doses given. Since acrolein and phosphorodiamidic acid mustard are the toxic decompn. products of aldophosphamide, and acrolein conjugation with glutathione appears to be the first step for MCA formation, values for MCA would reflect active I levels. The in vitro interaction of acrolein with glutathione, other sulfhydryl compds., and a few amino acids at concns. of 0.15 .mu.mols./ml was also studied. The faster interactions obsd. were with the sulfhydryl compds.; a 50% decrease of acrolein absorption was obsd. in interactions with glutathione and cysteine (at pH 7.4 and 23.degree.) in 111 and 30 sec, resp. Incubation of these acrolein-adducts at 37.degree. and 100.degree. generated acrolein with max. recovery yield of 83% at 100.degree.. Five patients given 1 g of I (i.v.) excreted 6.4-50.0 .mu.mols MCA in their urine in 6 h. .
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