CAS No.132-18-3,4-DIPHENYLMETHOXY-1-METHYLPIPERIDINE HYDROCHLORIDE Suppliers,MSDS download

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Basic Information

Molecular Structure:
CAS No.:	132-18-3
Name:	4-DIPHENYLMETHOXY-1-METHYLPIPERIDINE HYDROCHLORIDE

Formula:	C19H23 N O . Cl H
Molecular Weight:	317.859
Synonyms:	Piperidine,4-(diphenylmethoxy)-1-methyl-, hydrochloride (6CI,8CI,9CI); 1-Methyl-4-piperidylbenzhydryl ether hydrochloride; 4-Diphenylmethoxy-1-methylpiperidinehydrochloride; Anginosan; Belfene; Dayfen; Diafen; Diafen (antihistamine);Diafen hydrochloride; Diaphen; Diphenpyraline hydrochloride; Diphenylpyralinehydrochloride; Diphenylpyraline teoclate; Hispril; Hispril hydrochloride;Histryl; Histryl Spansule Capsules; Histyn; Kolton Jelly; Lergoban; Lergobine;Sumadil
EINECS:	205-049-3
Density:	g/cm³
Melting Point:	203-205 °C(lit.)
Boiling Point:	378.7°Cat760mmHg
Flash Point:	111.6°C
Hazard Symbols:
Risk Codes:	R20/21/22;R36/37/38
Safety:	Poison by ingestion, subcutaneous, intramuscular, and intravenous routes. When heated to decomposition it emits toxic fumes of NO_x and HCl.
PSA:	12.47000
LogP:	4.62670

Synthetic route

: cobalt(II) chloride hexahydrate

: 132-18-3
diphenylpyraline hydrochloride

: 145519-05-7
{Co(CH3NC5H9OCH(C6H5)2)2(H2O)2Cl2}

Conditions

Conditions	Yield
In ethanol addn. of soln. of diphenyl pyraline hydrochloride (0.02 mol) in ethanol to soln. of CoCl2*6H2O (0.01 mol) in ethanol; keeping at room temp. for 10 min, then warming to 60°C for 30 min (water bath);; pptn.; filtering, washing with cold ethanol and with ether, drying over P4O10; elem. anal.;;	82%

: 132-18-3
diphenylpyraline hydrochloride

: copper(II) nitrate

: 203715-86-0
Cu(C19H23NO)2(NO3)2

Conditions

Conditions	Yield
In ethanol byproducts: HCl; stirring (60-70°C, 0.5-10.0 h); pptn. on cooling, washing (EtOH), drying; elem. anal.;	82%

: 132-18-3
diphenylpyraline hydrochloride

: copper dichloride

: 203715-85-9
Cu(C19H23NO)2Cl2

Conditions

Conditions	Yield
In ethanol byproducts: HCl; stirring (60-70°C, 0.5-10.0 h); pptn. on cooling, washing (EtOH), drying; elem. anal.;	80%

: 132-18-3
diphenylpyraline hydrochloride

: copper(II) perchlorate

: 203715-88-2
Cu(C19H23NO)2(ClO4)2

Conditions

Conditions	Yield
In ethanol byproducts: HCl; stirring (60-70°C, 0.5-10.0 h); pptn. on cooling, washing (EtOH), drying; elem. anal.;	74%

: 6147-53-1
cobalt(II) diacetate tetrahydrate

: 132-18-3
diphenylpyraline hydrochloride

: 145519-09-1
{Co(CH3NC5H9OCH(C6H5)2)2(H2O)2(CH3CO2)2}

Conditions

Conditions	Yield
In ethanol addn. of soln. of diphenyl pyraline hydrochloride (0.02 mol) in ethanol to soln. of Co(CH3CO2)2*4H2O (0.01 mol) in ethanol; stirring vigorously at room temp. for 30 min;; pptn.; filtering, washing with cold ethanol and with ether, drying on air; elem. anal.;;	68%

: cobalt(II) nitrate hexahydrate

: 132-18-3
diphenylpyraline hydrochloride

: 145519-06-8
{Co(CH3NC5H9OCH(C6H5)2)2(H2O)2(NO3)2}

Conditions

Conditions	Yield
In ethanol addn. of soln. of diphenyl pyraline hydrochloride (0.02 mol) in ethanol to soln. of Co(NO3)2*6H2O (0.01 mol) in ethanol; stirring vigorously at room temp. for 30 min;; pptn.; filtering, washing with cold ethanol and with ether, drying on air; elem. anal.;;	67%

: cobalt(II) perchlorate

: 132-18-3
diphenylpyraline hydrochloride

: 145519-08-0
{Co(CH3NC5H9OCH(C6H5)2)2(H2O)2(ClO4)2}

Conditions

Conditions	Yield
In ethanol addn. of soln. of diphenyl pyraline hydrochloride (0.02 mol) in ethanol to soln. of Co(ClO4)2 (0.01 mol) in ethanol; stirring vigorously at room temp. for 30 min;; pptn.; filtering, washing with cold ethanol and with ether, drying on air; elem. anal.;;	62%

: 142-71-2
copper diacetate

: 132-18-3
diphenylpyraline hydrochloride

: 203715-87-1
Cu(C19H23NO)2(CH3COO)2

Conditions

Conditions	Yield
In ethanol byproducts: HCl; stirring (60-70°C, 0.5-10.0 h); pptn. on cooling, washing (EtOH), drying; elem. anal.;	57%

: cobalt(II) sulphate heptahydrate

: 132-18-3
diphenylpyraline hydrochloride

: Co(2+)*2CH3NC5H9OCH(C6H5)2*2H2O*SO4(2-)={Co(CH3NC5H9OCH(C6H5)2)2(H2O)2(SO4)}

Conditions

Conditions	Yield
In ethanol addn. of soln. of diphenyl pyraline hydrochloride (0.02 mol) in ethanol to soln. of CoSO4*7H2O (0.01 mol) in ethanol; keeping at room temp. for 10 min, then warming to 60°C for 30 min (water bath);; pptn.; filtering, washing with cold ethanol and with ether, drying over P4O10; elem. anal.;;	41%

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Chemistry

IUPAC Name: 4-Benzhydryloxy-1-methylpiperidine hydrochloride
The MF of 4-Benzhydryloxy-1-methylpiperidine hydrochloride (CAS NO.132-18-3) is C₁₉H₂₄ClNO.

The MW of 4-Benzhydryloxy-1-methylpiperidine hydrochloride (CAS NO.132-18-3) is 317.85.
Synonyms of 4-Benzhydryloxy-1-methylpiperidine hydrochloride (CAS NO.132-18-3): 4-(Benzhydryloxy)-N-methylpiperidine Hydrochloride ; Anginosan ; Diphenylpyraline hydrochloride ; Histryl ; Histyn ; Kolton ; Diaphen
Product Categories: API intermediates
Flash Point: 111.6 °C
Boiling Point: 378.7 °C
Melting Point: 203-205 °C
Merck: 13,3363
EINECS: 205-049-3

Toxicity Data With Reference

1.	orl-rat LD50:698 mg/kg	NIIRDN “Drugs in Japan. Ethical Drugs, 6th Edition 1982” Edited by Japan Pharmaceutical Information Center. 6 (1982),333.
2.	scu-rat LD50:278 mg/kg	NIIRDN “Drugs in Japan. Ethical Drugs, 6th Edition 1982” Edited by Japan Pharmaceutical Information Center. 6 (1982),333.
3.	ivn-rat LD50:28,800 µg/kg	NIIRDN “Drugs in Japan. Ethical Drugs, 6th Edition 1982” Edited by Japan Pharmaceutical Information Center. 6 (1982),333.
4.	ims-rat LD50:180 mg/kg	NIIRDN “Drugs in Japan. Ethical Drugs, 6th Edition 1982” Edited by Japan Pharmaceutical Information Center. 6 (1982),333.
5.	orl-mus LD50:202 mg/kg	NIIRDN “Drugs in Japan. Ethical Drugs, 6th Edition 1982” Edited by Japan Pharmaceutical Information Center. 6 (1982),333.
6.	scu-mus LD50:112 mg/kg	NIIRDN “Drugs in Japan. Ethical Drugs, 6th Edition 1982” Edited by Japan Pharmaceutical Information Center. 6 (1982),333.
7.	ivn-mus LD50:31,800 µg/kg	NIIRDN “Drugs in Japan. Ethical Drugs, 6th Edition 1982” Edited by Japan Pharmaceutical Information Center. 6 (1982),333.
8.	ims-mus LD50:64,300 µg/kg	NIIRDN “Drugs in Japan. Ethical Drugs, 6th Edition 1982” Edited by Japan Pharmaceutical Information Center. 6 (1982),333.

Consensus Reports

Reported in EPA TSCA Inventory.

Safety Profile

Poison by ingestion, subcutaneous, intramuscular, and intravenous routes. When heated to decomposition it emits toxic fumes of NO_x and HCl.Safety information of 4-Benzhydryloxy-1-methylpiperidine hydrochloride (CAS NO.132-18-3):
Hazard Codes Harmful Xn
Risk Statements
20/21/22 Harmful by inhalation, in contact with skin and if swallowed
36/37/38 Irritating to eyes, respiratory system and skin
Safety Statements
26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
36 Wear suitable protective clothing
RIDADR 3249
WGK Germany 3
RTECS TM7823600
HazardClass 6.1(b)
PackingGroup III