Detail of "132-93-4"

Reference

Light scattering studies on micelle formation by some penicillins in aqueous solutions

Light scattering studies on micelle formation by some penicillins in aqueous solutions. Attwood, D.; Agarwal, S. P. (Pharm. Dep., Univ. Manchester, Manchester M13 9PL, UK). J. Pharm. Pharmacol., 36(8), 563-4 (English) 1984. CODEN: JPPMAB. ISSN: 0022-3573. DOCUMENT TYPE: Journal CA Section: 63 (Pharmaceuticals) The aggregation of a no. of penicillins, both in water and in electrolyte soln., was examd. by total intensity light scattering methods. Micellar assocn. was noted for Na carfecillin [21649-57-0], Na flucloxacillin [1847-24-1], cloxacillin [61-72-3], phenethicillin potassium salt [132-93-4] and penicillin V potassium salt [132-98-9] and crit. micelle concns. and micellar aggregation nos. were detd. Assocn. of penicillin G potassium salt [113-98-4] in water and electrolyte was limited to dimer and trimer formation.

Comparative pharmacodynamics and clinical pharmacokinetics of phenoxymethylpenicillin and pheneticillin

Comparative pharmacodynamics and clinical pharmacokinetics of phenoxymethylpenicillin and pheneticillin. Overbosch, D.; Mattie, H.; Van Furth, R. (Dep. Infect. Dis., Univ. Hosp., Leiden 2333 AA, Neth.). Br. J. Clin. Pharmacol., 19(5), 657-68 (English) 1985. CODEN: BCPHBM. ISSN: 0306-5251. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Section cross-reference(s): 10 The antimicrobial effects of phenoxymethylpenicillin (PM) [87-08-1] and pheneticillin (PE) [147-55-7] in vitro and in an exptl. animal infection model were compared; pharmacokinetics of both the drugs were also studied in patients. For the inhibitory effect of PM on short-term (3 h) growth of Staphylococcus aureus in vitro, this drug was 2.13 times more potent than PE. The protein binding of both drugs was similar (78-80%). The potency ratio of PM to PE against S. aureus in an exptl. mouse-thigh infection was only 1.25 to 1. This is explained by the difference in the area under the curve after s.c. administration of PM (0.47 mg/L h) and PE (0.92 mg/L h). The plasma clearance after i.v. administration of PM was 476.4 mL/min and that of PE was 295.1 mL/min; the plasma clearance of both drugs was strongly correlated with the creatinine clearance. The vol. of distribution in the steady state of PM was 35.4 L and that of PE 22.5 L. In 10 patients, the absorption after oral administration of PM as the acid was 48% and that of the K salt of PE [132-93-4] was 86% of the dose. Thus, a difference in effectiveness of different formulations of PM and PE would depend entirely on differences in absorption.