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CAS No.: | 13223-25-1 |
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Name: | 2-Chloro-4,6-dimethoxypyrimidine |
Article Data: | 6 |
Molecular Structure: | |
Formula: | C6H7ClN2O2 |
Molecular Weight: | 174.587 |
Synonyms: | 4,6-Dimethoxy-2-chloropyrimidine;AC1NP78R;61336_ALDRICH;AC1Q49B7;61336_FLUKA; |
EINECS: | 603-561-5 |
Density: | 1.285 g/cm3 |
Melting Point: | 100-105 °C |
Boiling Point: | 317.1 °C at 760 mmHg |
Flash Point: | 145.6 °C |
Solubility: | Insoluble in water, soluble in toluene, isopropyl alcohol |
Appearance: | white powder |
Hazard Symbols: | Xn,Xi |
Risk Codes: | 22-36-36/37/38 |
Safety: | 26 |
PSA: | 44.24000 |
LogP: | 1.14720 |
2-chloro-4,6-dimethoxypyrimidine
Conditions | Yield |
---|---|
With hydrogenchloride In methanol at 5℃; for 2h; Temperature; | 82.1% |
4,6-dimethoxy-2-aminopyrimidine
2-chloro-4,6-dimethoxypyrimidine
Conditions | Yield |
---|---|
With hydrogenchloride; sodium hydroxide; sodium nitrite In water; ethyl acetate | 29.9% |
With hydrogenchloride; zinc(II) chloride; sodium nitrite Chlorination; |
2-chloro-4,6-dimethoxypyrimidine
2-chloro-4,6-dimethoxy-5-nitro-pyrimidine
Conditions | Yield |
---|---|
With trifluoromethylsulfonic anhydride; tetramethylammonium nitrate In dichloromethane at 20℃; for 38h; | 98% |
Stage #1: 2-chloro-4,6-dimethoxypyrimidine With trifluoromethylsulfonic anhydride; tetramethylammonium nitrate In dichloromethane at 0 - 20℃; for 50.75h; Stage #2: With sodium hydrogencarbonate In dichloromethane; water | 97% |
With nitric acid; trifluoroacetic anhydride In dichloromethane at 20℃; | 97% |
phenylpropyolic acid
2-chloro-4,6-dimethoxypyrimidine
4,6-dimethoxy-2-(phenylethynyl)pyrimidine
Conditions | Yield |
---|---|
With bis[dicyclohexyl(2,4,6-triisopropyl-[1,1':3',1''-terphenyl]-2-yl)phosphane]palladium(II) dichloride; caesium carbonate In tetrahydrofuran at 80℃; for 10h; | 98% |
4-phenyl-1-piperazine
2-chloro-4,6-dimethoxypyrimidine
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine In isopropyl alcohol at 160℃; for 0.0833333h; Irradiation; | 97% |
benzofuran-2-boronic acid
2-chloro-4,6-dimethoxypyrimidine
2-(benzofuran-2-yl)-4,6-dimethoxypyrimidine
Conditions | Yield |
---|---|
With (η3-indenyl)Pd(XPhos)(OTf); potassium carbonate In tetrahydrofuran; methanol at 40℃; for 1h; Suzuki-Miyaura Coupling; Glovebox; Sealed tube; Cooling with ethanol-dry ice; | 97% |
With potassium phosphate; chloro(2-dicyclohexylphosphino-2’,4’,6’-triisopropyl-1,1‘-biphenyl)[2-(2’-amino-1,1‘-biphenyl’)]palladium(II) In tetrahydrofuran; water at 40℃; for 0.5h; Suzuki-Miyaura cross-coupling; Inert atmosphere; | 96% |
With C46H64ClPPd; potassium carbonate In tetrahydrofuran; methanol at 40℃; for 1h; Reagent/catalyst; Suzuki-Miyaura Coupling; Inert atmosphere; | 95% |
With [(η3-1-tBu-indenyl)Pd(1,3-bis(2,6-diisopropylphenyl)-1,3-dihydro-2H-imidazol-2-ylidene)(Cl)]; potassium carbonate In tetrahydrofuran; methanol at 20℃; for 3h; Reagent/catalyst; Time; Suzuki-Miyaura Coupling; Inert atmosphere; |
2-chloro-4,6-dimethoxypyrimidine
4,6-dimethoxy-2-aminopyrimidine
Conditions | Yield |
---|---|
With ammonia In tetrahydrofuran; water at 100 - 110℃; for 4h; Solvent; Autoclave; Large scale; | 96.3% |
With dicyclohexyl(2',4',6'-triisopropyl-5-methoxy-3,4,6-trimethyl-[1,1'-biphenyl]-2-yl)phosphine; C50H70NO4PPdS; C50H70NO4PPdS; dicyclohexyl(2',4',6'-triisopropyl-4-methoxy-3,5,6-trimethyl-[1,1'-biphenyl]-2-yl)phosphine; ammonia; sodium t-butanolate In 1,4-dioxane at 50℃; for 24h; Reagent/catalyst; Inert atmosphere; | 80% |
Multi-step reaction with 2 steps 1: potassium carbonate / 1,4-dioxane / 96 h / Reflux 2: methanol; palladium(II) hydroxide / 48 h / 20 °C View Scheme | |
Multi-step reaction with 2 steps 1: potassium carbonate / 1,4-dioxane / 96 h / Reflux 2: hydrogen; palladium(II) hydroxide / methanol / 48 h / 20 °C / 760.05 Torr View Scheme |
Conditions | Yield |
---|---|
With O4P(3-)*3K(1+)*5H2O; tris(1-adamantyl)phosphine; C28H26N2O8Pd2S2 In tetrahydrofuran; butan-1-ol at 20℃; for 5h; Suzuki-Miyaura Coupling; Inert atmosphere; Schlenk technique; | 96% |
With O4P(3-)*3K(1+)*5H2O; tris(1-adamantyl)phosphine; {2-[((acetyl-κO)amino)phenyl-κC](tri-1-adamantylphosphine)palladium}(p-toluenesulfonate) In tetrahydrofuran; butan-1-ol at 20℃; for 5h; Suzuki-Miyaura Coupling; | 96% |
2-chloro-4,6-dimethoxypyrimidine
sodium thiomethoxide
4,6-dimethoxy-2-(methylsulfanyl)pyrimidine
Conditions | Yield |
---|---|
In methanol at 45 - 50℃; for 2h; | 95.6% |
1-methyl-piperazine
2-chloro-4,6-dimethoxypyrimidine
4,6-dimethoxy-2-(4-methylpiperazin-1-yl)pyrimidine
Conditions | Yield |
---|---|
In N,N-dimethyl-formamide at 90℃; for 2.5h; Inert atmosphere; | 95% |
In N,N-dimethyl-formamide at 90℃; for 2.5h; Inert atmosphere; | 95% |
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The 2-Chloro-4,6-dimethoxypyrimidine with CAS registry number of 13223-25-1 is also known as Pyrimidine,2-chloro-4,6-dimethoxy-. The IUPAC name and product name are the same. It belongs to product categories of Pyrimidine; Pyrimidines; Building Blocks; Heterocyclic Building Blocks; Dimethoxy pyrimidines. In addition, the formula is C6H7ClN2O2 and the molecular weight is 174.59.
Physical properties about 2-Chloro-4,6-dimethoxypyrimidine are: (1)ACD/LogP: 0.07; (2)ACD/LogD (pH 5.5): 0.07; (3)ACD/LogD (pH 7.4): 0.07; (4)ACD/BCF (pH 5.5): 1; (5)ACD/BCF (pH 7.4): 1; (6)ACD/KOC (pH 5.5): 26.04; (7)ACD/KOC (pH 7.4): 26.04; (8)#H bond acceptors: 4; (9)#Freely Rotating Bonds: 2; (10)Index of Refraction: 1.51; (11)Molar Refractivity: 40.68 cm3; (12)Molar Volume: 135.8 cm3; (13)Surface Tension: 41.5 dyne/cm; (14)Density: 1.285 g/cm3; (15)Flash Point: 145.6 °C; (16)Enthalpy of Vaporization: 53.63 kJ/mol; (17)Boiling Point: 317.1 °C at 760 mmHg; (18)Vapour Pressure: 0.00073 mmHg at 25 °C.
Preparation of 2-Chloro-4,6-dimethoxypyrimidine: it is prepared by reaction of malononitrile. 3-Amino-3-methoxy-N-cyano-2-C amidine intermediate is received and dispersed in toluene. Then dry hydrogen chloride is passed at the temperature of 0 °C under stirring for 2 hours. After reaction, adding water to the mixture and the water layer is extracted with toluene. At last, product is obtained by combining toluene solution, vacuum steam and drying.
Uses of 2-Chloro-4,6-dimethoxypyrimidine: it is used as pesticide intermediate and used to produce 7-(4,6-dimethoxy-pyrimidin-2-ylsulfanyl)-3-methyl-3H-isobenzofuran-1-one by reaction with 7-mercapto-3-methyl-3H-isobenzofuran-1-one. The reaction occurs with reagents K2CO3, triphenylphosphine and solvent acetonitrile at the temperature of 55 °C for 23 hours. The yield is about 91.1%.
When you are using this chemical, please be cautious about it. As a chemical, it is irritating to eyes, respiratory system and skin. Besides, it is harmful if swallowed. If contact with eyes accidently, rinse immediately with plenty of water and seek medical advice.
You can still convert the following datas into molecular structure:
1. Canonical SMILES: COC1=CC(=NC(=N1)Cl)OC
2. InChI: InChI=1S/C6H7ClN2O2/c1-10-4-3-5(11-2)9-6(7)8-4/h3H,1-2H3
3. InChIKey: PBEKEFWBLFBSGQ-UHFFFAOYSA-N