Detail of "13297-18-2"

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Synthesis of 1-hydrazinopyridazino[4,5-b]quinoxaline and related compounds

Synthesis of 1-hydrazinopyridazino[4,5-b]quinoxaline and related compounds. Monge Vega, A.; Gil, M. J.Several substances are used for example 13297-18-2 which is its cas registry number.; Fernandez-Alvarez, E. (Fac. Farm., Univ. Navarra, Pamplona, Spain). J.Chemical with cas number 13297-18-2 also plays role. Heterocycl. Chem., 21(5), 1271-6 (English) 1984. CODEN: JHTCAD. ISSN: 0022-152X. DOCUMENT TYPE: Journal CA Section: 28 (Heterocyclic Compounds (More Than One Hetero Atom)) Section cross-reference(s): 1 Chlorination of 2-ethoxycarbonyl-3-methylquinoxaline 1,4-dioxide (I) in HOAc gave 2-ethoxycarbonyl-3-dichloromethylquinoxaline-1,4-dioxide (II) which reacted with an excess N2H4 to give ~60% 1,2-dihydro-1-oxopyridazino[4,5-b]quinoxaline (III). Oxidn. of I with Se2O2 gave 90% 2-ethoxycarbonyl-3-formylquinoxaline 1,4-dioxide (IV) which reacted with N2H4 to give 63% III. Treatment of IV with N2H4 gave 1,2-dihydro-1-oxopyridazino[4,5-b]quinoxaline 1,4-dioxide which by redn. with Na dithionite gave 80% III. III reacted with P2S5 or Lawesson reagent to give 1,2-dihydro-1-thioxopyridazino[4,5-b]quinoxaline which on treatment with N2H4 gave 1-hydrazinopyridazino[4,5-b]quinoxaline (V). V reacted with HNO2 to give tetrazolo[4,3-b]pyridazino[4,5-b]quinoxaline. Some hydrazones of V were also prepd. Heating of the hydrazones with Me2SO gave 1,2,4-triazolo[4,3-b]pyridazino[4,5-b]quinoxalines. Reaction of IV with PhNHNH2 gave 1,2-dihydro-1-oxo-2-phenylpyridazino[4,5-b]quinoxaline. Reaction of III with Ac2O or Me2SO4 gave 1-acetoxypyridazino[4,5-b]quinoxaline and 1,2-dihydro-1-oxo-2-methylpyridazino[4,5-b]quinoxaline resp. III and V had antihypertensive activity in rats. ..

Synthesis of 1-hydrazinopyridazino[4,5-b]quinoxaline and related compounds

Synthesis of 1-hydrazinopyridazino[4,5-b]quinoxaline and related compounds. Monge Vega, A.; Gil, M. J.Several substances are used for example 13297-18-2 which is its cas registry number.; Fernandez-Alvarez, E. (Fac. Farm., Univ. Navarra, Pamplona, Spain). J.Chemical with cas number 13297-18-2 also plays role. Heterocycl. Chem., 21(5), 1271-6 (English) 1984. CODEN: JHTCAD. ISSN: 0022-152X. DOCUMENT TYPE: Journal CA Section: 28 (Heterocyclic Compounds (More Than One Hetero Atom)) Section cross-reference(s): 1 Chlorination of 2-ethoxycarbonyl-3-methylquinoxaline 1,4-dioxide (I) in HOAc gave 2-ethoxycarbonyl-3-dichloromethylquinoxaline-1,4-dioxide (II) which reacted with an excess N2H4 to give ~60% 1,2-dihydro-1-oxopyridazino[4,5-b]quinoxaline (III). Oxidn. of I with Se2O2 gave 90% 2-ethoxycarbonyl-3-formylquinoxaline 1,4-dioxide (IV) which reacted with N2H4 to give 63% III. Treatment of IV with N2H4 gave 1,2-dihydro-1-oxopyridazino[4,5-b]quinoxaline 1,4-dioxide which by redn. with Na dithionite gave 80% III. III reacted with P2S5 or Lawesson reagent to give 1,2-dihydro-1-thioxopyridazino[4,5-b]quinoxaline which on treatment with N2H4 gave 1-hydrazinopyridazino[4,5-b]quinoxaline (V). V reacted with HNO2 to give tetrazolo[4,3-b]pyridazino[4,5-b]quinoxaline. Some hydrazones of V were also prepd. Heating of the hydrazones with Me2SO gave 1,2,4-triazolo[4,3-b]pyridazino[4,5-b]quinoxalines. Reaction of IV with PhNHNH2 gave 1,2-dihydro-1-oxo-2-phenylpyridazino[4,5-b]quinoxaline. Reaction of III with Ac2O or Me2SO4 gave 1-acetoxypyridazino[4,5-b]quinoxaline and 1,2-dihydro-1-oxo-2-methylpyridazino[4,5-b]quinoxaline resp. III and V had antihypertensive activity in rats. ..