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CAS No.: | 133-08-4 |
---|---|
Name: | Diethyl butylmalonate |
Article Data: | 65 |
Molecular Structure: | |
Formula: | C11H20O4 |
Molecular Weight: | 216.277 |
Synonyms: | Malonicacid, butyl-, diethyl ester (6CI,7CI,8CI);Propanedioic acid, butyl-, diethylester (9CI);Butylmalonic acid diethyl ester;Butylpropanedioic acid diethylester;Diethyl 2-butylmalonate;Diethyl n-butylmalonate;Diethyl a-butylmalonate;Ethylbutylmalonate;NSC 4565; |
EINECS: | 205-089-1 |
Density: | 0.994 g/cm3 |
Melting Point: | 119oC |
Boiling Point: | 237.5 °C at 760 mmHg |
Flash Point: | 93.9 °C |
Solubility: | 330mg/L at 20℃ |
Appearance: | clear colourless liquid |
Safety: | 24/25 |
PSA: | 52.60000 |
LogP: | 1.91900 |
Conditions | Yield |
---|---|
With potassium carbonate; perhydrodibenzo-18-crown-6; Aliquat In toluene at 80℃; for 5h; | 92% |
With 18-crown-6 ether; Hexamethyldisiloxane; Aliquat 336; potassium carbonate at 90℃; for 4h; Solvent; Inert atmosphere; Green chemistry; | 88% |
With sodium ethanolate In ethanol for 2h; Heating; | 87% |
Conditions | Yield |
---|---|
Stage #1: diethyl malonate With copper(l) chloride for 1.5h; Large scale; Stage #2: N-butylamine for 10h; Time; Reflux; Large scale; | 92% |
1-bromo-butane
diethyl malonate
A
diethyl dibutylmalonate
B
diethyl butylmalonate
Conditions | Yield |
---|---|
With sodium ethanolate In ethanol | A 4% B 75% |
tetrabutyl phosphonium bromide; potassium carbonate at 170℃; under 20 Torr; Product distribution; other catalysts, other compounds, other products; |
Conditions | Yield |
---|---|
With tributylphosphine; 4,7-dimethyl-3,5,7-hexahydro-1,2,4,7-tetrazocin-3,8-dione In benzene for 24h; Ambient temperature; | 64% |
With tributylphosphine; 1,1'-azodicarbonyl-dipiperidine In benzene 1) 0 deg C, 10 min, 2) RT, 24 h; | 21% |
1-bromo-butane
sodium diethylmalonate
diethyl butylmalonate
Conditions | Yield |
---|---|
With ethanol Darst.; |
diethyl butylidenemalonate
diethyl butylmalonate
Conditions | Yield |
---|---|
With ethanol; nickel under 73550.8 - 95616 Torr; Hydrogenation; | |
With palladium on activated charcoal; ethanol under 73550.8 - 147102 Torr; Hydrogenation; | |
With diethyl ether; nickel under 73550.8 - 95616 Torr; Hydrogenation; |
Conditions | Yield |
---|---|
With sodium ethanolate at 50 - 60℃; under 100 Torr; unter Abdestillieren des entstehenden Aethanols und Erhitzen des Reaktinsprodukts unter vermindertem Druck auf 160grad; |
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Molecular Structure:
Molecular Formula: C11H20O4
Molecular Weight: 216.2741
IUPAC Name: Diethyl 2-butylpropanedioate
Synonyms of Propanedioic acid,2-butyl-, 1,3-diethyl ester (CAS NO.133-08-4): AI3-06356 ; EINECS 205-089-1 ; Diethyl butylmalonate ; Propanedioic acid, butyl-, diethyl ester
CAS NO: 133-08-4
Classification Code: Pharmaceutical Intermediates ; TheMalonateRamificationProducts ; C10 to C11 ; Carbonyl Compounds ; Esters
Index of Refraction: 1.433
Molar Refractivity: 56.51 cm3
Molar Volume: 217.4 cm3
Surface Tension: 31.8 dyne/cm
Density: 0.994 g/cm3
Flash Point: 93.9 °C
Enthalpy of Vaporization: 47.43 kJ/mol
Boiling Point: 237.5 °C at 760 mmHg
Vapour Pressure: 0.0447 mmHg at 25°C
Propanedioic acid,2-butyl-, 1,3-diethyl ester (CAS NO.133-08-4) is used as the organic synthesis intermediate, it is mainly used in the medicine manufacture, it is always a fever medicine and so on analgesic phenylbutazone raw materials.
Safety Statements of Propanedioic acid,2-butyl-, 1,3-diethyl ester (CAS NO.133-08-4): 24/25
S24/25: Avoid contact with skin and eyes.
WGK Germany: 1
HS Code: 29171990