Detail of "133-16-4"

CAS Number:
133-16-4
Name:
Benzoic acid,4-amino-2-chloro-, 2-(diethylamino)ethyl ester
Superlist Name:
2-Diethylaminoethyl 4-amino-2-chloro-benzoate
Molecular Structure:
Formula:
C₁₃H₁₉ClN₂O₂
Molecular Weight:
270.79
Synonyms:
2-Chloroprocaine;2-Diethylaminoethyl 4-amino-2-chlorobenzoate;Chloroprocain;Chloroprocaine;Chlorprocaine;Halestyn;Piocaine;
Density:
1.17 g/cm³
Boiling Point:
402.632 °C at 760 mmHg
Flash Point:
197.305 °C

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Assay:98%

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Simultaneous determination of chloroprocaine hydrochloride and its degradation product 4-amino-2-chlorobenzoic acid in bulk drug and injection solutions by high-performance liquid chromatography: Simultaneous determination of chloroprocaine hydrochloride and its degradation product 4-amino-2-chlorobenzoic acid in bulk drug and injection solutions by high-performance liquid chromatography. Menon, G.Some chemicals with cas registry numbers like 133-16-4 and 2457-76-3 are also used.; Norris, B.; Webster, J. (Dep. Anal. Res., Abbott Lab., North Chicago, IL 60064, USA). J. Pharm. Sci., 73(2), 251-3 (English) 1984. CODEN: JPMSAE. ISSN: 0022-3549. DOCUMENT TYPE: Journal CA Section: 64 (Pharmaceutical Analysis) A high-performance liq. chromatog. method was developed for the simultaneous detn. of chloroprocaine (I) [133-16-4] and its hydrolytic degrdn. product, 4-amino-2-chlorobenzoic acid (II) [2457-76-3]. Sepn. is achieved using a m-Bondapak C18 column and the eluant, H2O-MeCN-MeOH-AcOH (:5:1) contg. 0.05-0.08% (wt./vol.) Na 1-heptanesulfonate, at a flow rate of 2 mL/min. Benzoic acid and p-nitroacetophenone were used as internal stds. A variable-wavelength UV detector (278 nm) was used for detection of the compds. The method is simple, accurate, and precise. .

Dissociation constants of local anesthetics and their temperature dependence: Dissociation constants of local anesthetics and their temperature dependence. Kamaya, Hiroshi; Hayes, John J., Jr.; Ueda, Issaku (Coll. Med., Univ. Utah, Salt Lake City, UT 84148, USA). Anesth. Analg. (N. Y.), 62(11), 1025-30 (English) 1983. CODEN: AACRAT. ISSN: 0003-2999. DOCUMENT TYPE: Journal CA Section: 63 (Pharmaceuticals) Section cross-reference(s): 1, 22 The effect of temp. on the dissocn. consts. of tetracaine [94-24-6], procaine [59-46-1], mepivacaine [96-88-8], bupivacaine [2180-92-9], chloroprocaine [133-16-4], lidocaine [137-58-6] and dibucaine [85-79-0] was detd. The dissocn. consts. increased (pKa decreased) with increasing temp. Thus, high temp. favors the unchanged species (in the equil.). The dissocn. const. obtained at room temp. 133-16-4 and 96-88-8 which are cas registry numbers of chemicals are mentioned. gives an erroneous idea about the ratio between the 2 species. The correct values at physiol. temp. are necessary for analyzing the anesthetic action. Problems assocd. with the use of the Henderson-Hasselbach (H-H) equation are given. The dissocn. const. is math. defined and a rigorous form of the H-H equation is given. .