Detail of "133-49-3"

Reference

Evidence for the active renal secretion of S-pentachlorophenyl-N-acetyl-L-cysteine by female rats

Evidence for the active renal secretion of S-pentachlorophenyl-N-acetyl-L-cysteine by female rats. Smith, Andrew G.; Francis, Jean E. (Med. Res. Counc. Lab., MRC, Carshalton/Surrey SM5 4EF, UK). Biochem. Pharmacol., 32(24), 3797-801 (English) 1983. CODEN: BCPCA6. ISSN: 0006-2952. DOCUMENT TYPE: Journal CA Section: 4 (Toxicology) Male and female rats received 50 mmol pentachloronitrobenzene [82-68-8]/kg by oral intubation daily for 7 days. The final excreta were hydrolyzed and analyzed by electron capture gas-liq. chromatog. for the presence of pentachlorobenzenethiol [133-49-3] and tetrachloro-1,4-benzenedithiol [67341-48-4] (derived from the equiv. N-acetylcysteine conjugates). No differences were found between the sexes for feces and bile but the urinary excretion of both thiols by females was >10-fold greater than males. A similar result for urine was obtained following i.p. administration of a single 20-mmol/kg dose of S-pentachlorophenyl-N-acetyl-L-cysteine (I) [68593-98-6]; in addn., cotreatment with probenecid did not greatly change excretion by the males but considerably reduced excretion by females. The sex difference in the urinary levels of I after 40 and 100 mmol/kg pentachloronitrobenzene was confirmed by high-performance liq. chromatog. of I and again probenecid inhibited the excretion. Anal. of urine by TLC following a dose of 14C-labeled hexachlorobenzene [118-74-1] (8 mCi/kg; 0.67 mmol/kg) showed that more radioactivity was assocd. with I from female rats than males. Thus, I, a metabolite of hexachlorobenzene and pentachloronitrobenzene, may be excreted by an active renal secretion which is particularly developed in female F344 rats.

Studies on the toxicology of hexachlorobenzene

Studies on the toxicology of hexachlorobenzene. II. Identification and determination of metabolites. Koss, G.; Koransky, W.; Steinbach, K. (Inst. Toxikol. Pharmakol., Philipps-Univ., Marburg, Ger.). Arch. Toxicol., 35(2), 107-14 (English) 1976. CODEN: ATXKA8. DOCUMENT TYPE: Journal CA Section: 4 (Toxicology) Female rats were dosed intraperitoneally with 14C-labeled hexachlorobenzene (I) [118-74-1]. The drug was administered on 2 or 3 occasions. The total doses amounted to 260 and 390 mg/kg. In urine pentachlorophenol [87-86-5], tetrachlorohydroquinone [87-87-6], andpentachlorothiophenol [133-49-3] were present as major metabolites. One of the isomers of tetrachlorothiophenol [60135-24-2] was present as a minor metabolite. In the feces pentachlorophenol and pentachlorothiophenol only were identified. Radioactive C excreted with urine and feces amounted to 7% and 27%, resp., of the radioactivity administered. More than 90% of C-14 excreted in urine was contained in the major metabolites. In the feces about 30% of the excreted radioactivity was bound to metabolites, and . 118-74-1 and 60135-24-2 which are cas registry numbers of chemicals are mentioned.apprx.70% was contained in the unchanged drug, while in the tissues of the animals only pentachlorophenol was detected in measurable amts., accounting for 10% of label in blood and <0.1% of C-14 detd. in body fat. Total radioactivity contained in the metabolites detected in the animal body and in the excreta accounted for .apprx.16% of the administered radioactivity. .