Reference

Development of candidate chemical simulant list: the evaluation of candidate chemical simulants which may be used in chemically hazardous operations

Development of candidate chemical simulant list: the evaluation of candidate chemical simulants which may be used in chemically hazardous operations. (Little, Arthur D., Inc.In this study， 112-55-0 and 1653-30-1 are also used., Cambridge, MA, USA). Report, ADL-87638-01, AFAMRL-TR-82-87; Order No. AD-B070947, 144 pp. Avail. NTIS From: Gov. Rep. Announce. Index (U. S.) 1984, 84(5), 302 (English) 1982. DOCUMENT TYPE: Report CA Section: 59 (Air Pollution and Industrial Hygiene) The objectives of this task were threefold: (1) to provide addnl. data for the proposed candidate simulants dipentene [138-86-3], methyl benzoate [93-58-3], and benzyl alc. [100-51-6] by means of in-depth literature searches encompassing both computerized data bases and a manual search of the older literature; (2) to fully evaluate 12 possible candidate simulants under more flexible simulant criteria; and (3) to develop a list of candidate simulants in the low and non-volatile categories. Computerized literature searches were conducted for the 12 possible candidate simulants under more flexible intake simulant criteria as well as for dimethylmethylphosphonate [756-79-6], a compd. selected for evaluation by the USAF. The 12 possible candidates included cyclohexanone [108-94-1], n-dodecanethiol [112-55-0], methyl salicylate [119-36-8], dihexyl ether [112-58-3], dypnone [495-45-4], n-aminopropyl morpholine [123-00-2], n-(2-hydroxyethyl)morpholine [622-40-2], butyl salicylate [2052-14-4], di(2-Et hexyl)ether, 2-undecanol [1653-30-1], 2-hydroxyethyl-n-octyl sulfide [3547-33-9], and n,n-diethyl-m-toluamide [134-62-3]. Full assesment of the potential health hazards assocd. with exposure to n-dodecanethiol, Me salicylate, Bu salicylate, and n,n-diethyl-m-toluamide was completed. All of these compds. meet the majority of USAF criteria for candidate simulants. Cyclohexanone was disqualified for reasons of toxicity, while the available toxicol. data for the 7 remaining candidates were considered inadequate for full assessment of hazard. .

Optimization of bioavailability of topical steroids: penetration enhancers under occlusion

Optimization of bioavailability of topical steroids: penetration enhancers under occlusion. Barry, Brian W.; Southwell, Diane; Woodford, Roger (Postgrad. Sch. Stud.Chemicals with cas numbers 68-12-2 and 2687-91-4 also play role. Pharm., Univ. Bradford, Bradford/West Yorkshire ED7 1DP, UK). J. Invest. Dermatol., 82(1), 49-52 (English) 1984. CODEN: JIDEAE. ISSN: 0022-202X. DOCUMENT TYPE: Journal CA Section: 63 (Pharmaceuticals) Section cross-reference(s): 2 The occluded vasoconstrictor assay was used to assess the effect of penetration enhancers on the topical bioavailability of a representative steroid, betamethasone 17-benzoate [22298-29-9], with dimethylisosorbide (DMI) as a ref. solvent. In the initial test, only N-methyl-2-pyrrolidone (NMP) [872-50-4] increased the steroid bioavailability; Me2CO [67-64-1], DMF [68-12-2], 2-pyrrolidone (2-P) [616-45-5], and 1-ethyl-2-pyrrolidone (EP) [2687-91-4] were equal to DMI, while propylene glycol (PG) [57-55-6] and N,N-diethyl-m-toluamide (DEET) [134-62-3] were poorer. Reocclusion showed that NMP and Me2CO established superior stratum corneum reservoirs; DMF, 2-P, EP, and PG were as effective as DMI but DEET was less effective. Occlusive hydration and lack of thermodn. control may have obscured the enhancing abilities of the solvents. 2-P, NMP, EP, DMF, and DEET induced erythema in some volunteers, although this was usually short-lived. .