Detail of "13412-64-1"

Reference

Cephalexin preparations containing cloxacillin and dicloxacillin

Cephalexin preparations containing cloxacillin and dicloxacillin. Saito, Tetsu; Morohoshi, Tashiro; Nishiumi, Shusaku; Ando, Takuji; Murase, Junichi (Toyo Jozo Co., Ltd., Japan). Japan. Kokai JP 52064432 27 May 1977 Showa, 8 pp. (Japanese). (Japan). CODEN: JKXXAF. CLASS: IC: A61K031-545. APPLICATION: JP 75-119450 6 Oct 1975. DOCUMENT TYPE: Patent CA Section: 63 (Pharmaceuticals) Cephalexin (I) [15686-71-2] prepns. contg. cloxacillin [61-72-3] or dicloxacillin (II) [3116-76-5] are effective against I-resistant bacteria and show an increased activity against I-susceptible bacteria. Thus, a capsule prepn. contains I (125 mg equiv. potency), dicloxacillin Na salt [13412-64-1] (62.5 mg equiv. potency), Mg stearate (7.0 mg) and Na dioctylsulfosuccinate (1.0 mg).

Suppression of the lytic and bactericidal effects of cell wall-inhibitory antibiotics

Suppression of the lytic and bactericidal effects of cell wall-inhibitory antibiotics. Lopez, Ruben; Ronda-Lain, Conchita; Tapia, Alfonso; Waks, Susan B.; Tomasz, Alexander (Inst. Immunol. Biol. Microbiana, Madrid, Spain). Antimicrob. Agents Chemother., 10(4), 697-706 (English) 1976. CODEN: AMACCQ. DOCUMENT TYPE: Journal CA Section: 3 (Biochemical Interactions) The bactiolytic effect of .beta.-lactam antibiotics on Bacillus subtilis and on Streptococcus pneumoniae was a function of the pH; lysis was suppressed if the pH of the pneumococcal culture was <6.0 during benzylpenicillin (I) [61-33-6] treatment. In the case of B. subtilis, growth at pH 6.6 prevented I induced lysis. In pneumococci, the addn. of trypsin to the growth medium also protected against lysis. The pH-dependent protection phenomenon resembled in several respects the antibiotic tolerance of pneumococci with a defective autolytic system. At the pH nonpermissive for lysis, the bacteria retained their normal sensitivity to .beta.-lactam and to other cell wall inhibitors; however, instead of lysis, the drug-treated bacteria simply stopped growing. Loss of viability of the cells was also greatly decreased. Protection against lysis was independent of the dose and chem. 13412-64-1 and 32887-01-7 are just another two chemicals used in this study. nature of the cell wall inhibitors. The protection effect was reversible; lysis and loss of viability could be triggered by a postincubation of the drug-treated bacteria at the pH permissive for lysis. .