Detail of "13456-39-8"

Reference

Effect of micellar interactions on base-catalyzed hydrolysis of procaine

Effect of micellar interactions on base-catalyzed hydrolysis of procaine. Tomida, Hisao; Yotsuyanagi, Toshihisa; Ikeda, Ken (Fac. Pharm. Sci., Nagoya City Univ., Nagoya, Japan). Chem. Pharm. Bull., 26(1), 148-54 (English) 1978. CODEN: CPBTAL. ISSN: 0009-2363. DOCUMENT TYPE: Journal CA Section: 63 (Pharmaceuticals) The modifying effects of polyoxyethylene lauryl ether (PLE) [9002-92-0], Na lauryl sulfate (SLS) [151-21-3], cetyltrimethylammonium bromide (CTAB) [57-09-0] and N-dodecylbetaine (NDB) [683-10-3] micelles on the rate of base-catalyzed hydrolysis of procaine-HCl (I) [51-05-8] were investigated. The retardation effect for the hydrolysis was obsd. in all surfactant solns. Partition coeffs. (K) to the micelles were calcd. from kobs and the partial molar vol. based on the phase sepn. model. The order of K was SLS>CTAB>NDB>PLE for the free base. In the cationic surfactant system, the corresponding p-nitroprocaine [13456-39-8] was also retarded in hydrolysis rate. These observations are contrary to the electrostatic theory. The effect of diethylaminoethyl moiety rather than p-substituents was apparently predominant in the solubilization mechanism. The detn. of partition coeffs. by the potentiometric method was made for PLE and CTAB systems and a fairly good agreement with the values from kinetic data was obtained. Nuclear magnetic resonance studies suggested that in the case of SLS and PLE the solubilization of I was related as far as the center portion of the micelle whereas the drug mol. was located at the outer layer for CTAB and NDB micelles.

Chemical regulation of carotenoid biosynthesis

Chemical regulation of carotenoid biosynthesis. Part 9. Synthetic regulators of carotenoid biosynthesis in Citrus paradisi. Poling, Stephen M.; Hsu, Wan-Jean; Yokoyama, Henry (Fruit Veg. Chem. Lab., Pasadena, Calif., USA). Phytochemistry, 15(11), 1685-7 (English) 1976. CODEN: PYTCAS. DOCUMENT TYPE: Journal CA Section: 3 (Biochemical Interactions) The ability of 16 amines to induce carotenoid biosynthesis in Marsh seedless grapefruit was correlated with the octanol-water partition coeff. and the Hammett consts. The compds. fell into 3 series: I (R = H, NH2, CN, NO2, MeO, Me, tert-Bu, F, Cl, Br) II (R = H, Me, NO2), and III (R = o-Me, m-Me, p-Me). Total carotene content increased up to 12-fold. Lycopene [502-65-8], no normally accumulated, became a major pigment. The benzoates caused up to a 24-fold increase in the .beta.-carotene [7235-40-7] content. Except for the larger accumulation of cyclic carotenes, the mode of action of these amines appears to be similar to that of 2-(4-chlorophenylthio)triethylamine hydrochloride.Except for chemicals metioned above, 13456-39-8 and 19881-34-6 are also used. .