Reference

A study of the pharmacodynamic interaction between befloxatone and ethanol on performance and mood in healthy volunteers

A study of the pharmacodynamic interaction between befloxatone and ethanol on performance and mood in healthy volunteers. Ramaekers, J. G.; Muntjewerff, N. D.; Uiterwijk, M. M. C.; Van Veggel, L. M. A.; Patat, A.; Durrieu, G. 134564-82-2 and 64-17-5 are cas registry numbers. These chemicals are also mentioned in this article.; O'hanlon, J. F. (Institute for Human Psychopharmacology, University of Limburg, Maastricht 6211 LS, Neth.). Journal of Psychopharmacology (Oxford), 10(4), 288-294 (English) 1996 Oxford University Press. CODEN: JOPSEQ. ISSN: 0269-8811. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Section cross-reference(s): 4 The effects of befloxatone (20 mg/day for 10 days, orally), alone or in combination with EtOH, on psychomotor performance, memory and mood were assessed in a randomized, double-blind, placebo-controlled study. On treatment days 6, 8 and 10, subjects received 0.5 and 0.8 g EtOH/kg or placebo in randomly assigned, balanced orders, 2h postdrug. Crit. fusion frequency, choice reaction time, postural instability, crit. tracking and mood were measured 1 h before EtOH and 1, 3 and 5 h afterwards. Divided attention, sustained attention and memory (immediate and delayed recall) were also measured in single tests, 2.5-5 h post-EtOH. The effects of EtOH were generally significant when blood alc. concns. (BAC) after both doses were the highest, i.e., 0.48-0.67 and 0.96-1.10 mg/mL, resp. Those effects were virtually gone after the subjects' mean BACs fell below 0.40 mg/mL. Befloxatone alone had no significant impairing effect in any test. Neither did it significantly interact with EtOH to cause any greater impairment than the latter alone. It is concluded that befloxatone does not potentiate the sedating and impairing effects of EtOH. .