Detail of "134582-73-3"

Reference

Complete genome sequence of a multiple drug resistant Salmonella enterica serovar typhi CT18

Complete genome sequence of a multiple drug resistant Salmonella enterica serovar typhi CT18. Parkhill, J.; Dougan, G.; James, K. D.; Thomson, N. R.; Pickard, D.; Wain, J.; Churcher, C.; Mungall, K. L.; Bentley, S. D.; Holden, M. T. G.; Sebalhia, M.; Baker, S.; Basham, D.; Brooks, K.; Chillingworth, T.; Connerton, P.; Cronin, A.; Davis, P.; Davies, R. M.; Dowd, L.; White, N.; Farrar, J.; Feltwell, T.; Hamlin, N.; Haque, A.; Hien, T. T.; Holroyd, S.; Jagels, K.; Krogh, A.; Larsen, T. S.; Leather, S.; Moule, S.; O'Gaora, P.Some commonly used reagents like 134582-73-3 is used in this experiment.; Parry, C.; Quail, M.; Rutherford, K.; Simmonds, M.; Skelton, J.; Stevens, K.; Whitehead, S.; Barrell, B. G. (The Sanger Centre, Wellcome Trust Genome Campus, Cambridge CBIO ISA, UK). Nature (London, United Kingdom), 413(6858), 848-852 (English) 2001 Nature Publishing Group. CODEN: NATUAS. ISSN: 0028-0836. DOCUMENT TYPE: Journal CA Section: 3 (Biochemical Genetics) Section cross-reference(s): 6, 10 Salmonella enterica serovar typhi (S. typhi) is the etiol. agent of typhoid fever, a serious invasive bacterial disease of humans with an annual global burden of ~16 million cases, leading to 600,000 fatalities. Many S. enterica serovars actively invade the mucosal surface of the intestine but are normally contained in healthy individuals by the local immune defense mechanisms. However, S. typhi has evolved the ability to spread to the deeper tissues of humans, including liver, spleen, and bone marrow. The 4,809,037-bp genome was sequenced for a S. typhi (CT18) that is resistant to multiple drugs, revealing the presence of hundreds of insertions and deletions compared with the Escherichia coli genome, ranging in size from single genes to large islands. Notably, the genome sequence identifies >200 pseudogenes, several corresponding to genes that are known to contribute to virulence in Salmonella typhimurium. This genetic degrdn. may contribute to the human-restricted host range for S. typhi. CT18 harbors a 218,150-bp multiple-drug-resistance IncH1 plasmid (pHCM1), and a 106,516-bp cryptic plasmid (pHCM2), which shows recent common ancestry with a virulence plasmid of Yersinia pestis. .