Detail of "13488-22-7"

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Comparative effects of indomethacin, acetylenic acids, 15-HETE, nordihydroguaiaretic acid and BW775C on the metabolism of arachidonic acid in human leukocytes and platelets

Comparative effects of indomethacin, acetylenic acids, 15-HETE, nordihydroguaiaretic acid and BW775C on the metabolism of arachidonic acid in human leukocytes and platelets. Salari, Hassan; Braquet, Pierre; Borgeat, Pierre (Cent. Hosp., Univ. Laval, Quebec, PQ G1V 4G2, Can.). Prostaglandins, Leukotrienes Med.Several reagents with their cas registry numbers 82249-77-2 and 1191-85-1 are used here., 13(1), 53-60 (English) 1984. CODEN: PLMEDD. ISSN: 0262-1746. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Section cross-reference(s): 2, 13, 14, 15 Human leukocytes and platelets were preincubated with inhibitors of the oxidative metab. of arachidonic acid [506-32-1], [indomethacin [53-86-1], BW755C [66000-40-6], 5,8,11,14-eicosatetraynoic acid (ETYA) [1191-85-1], 5,8,11-eicosatriynoic acid [13488-22-7], 15S-hydroxy-5,8,11,13-(Z,Z,Z,E)-eicosatetraenoic acid [54845-95-3] and nordihydroguaiaretic acid (NDGA) [500-38-9], prior to stimulation with the ionophore A23187 in the presence or absence of exogenous arachidonic acid. Eleven metabolites of arachidonic acid derived from the cyclooxygenase [39391-18-9] and the 5- [80619-02-9], 12- [82391-43-3], and 15-lipoxygenases [82249-77-2] were measured by reversed-phase high-pressure liq. chromatog. Indomethacin was the best inhibitor of the platelet cyclooxygenase (ID50 < 10-7M) as assessed by measurement of 12-hydroxyheptadecatrienoic acid [67870-51-3]; ETYA was the most potent inhibitor of the 12- and 15-lipoxygenases (ID50 ~ 3 ′ 10-7M), whereas NDGA was the most potent and selective inhibitor of the 5-lipoxygenase (ID50 ~ 3 ′ 10-7M). .

Possible involvement of lipoxygenase products of arachidonic acid pathway in ovulation

Possible involvement of lipoxygenase products of arachidonic acid pathway in ovulation. Reich, R.; Kohen, F.; Naor, Z.; Tsafriri, A. (Dep. Horm.Some commonly used reagents like 13488-22-7 and 66000-40-6 are used in this experiment. Res., Weizmann Inst. Sci., Rehovot 76100, Israel). Prostaglandins, 26(6), 1011-20 (English) 1983. CODEN: PRGLBA. ISSN: 0090-6980. DOCUMENT TYPE: Journal CA Section: 2 (Mammalian Hormones) The possible involvement of products of the lipoxygenase pathway of arachidonic acid [506-32-1] cascade in ovulation in the rat was tested by intrabursal injection of nordihydroguaiaretic acid (NDGA) [500-38-9], 5,8,11-eicosatriynoic acid [13488-22-7], 3-amino-1-(3-trifluromethyphenyl)-2-pyrazoline hydrochloride [66000-40-6], and FPL 55712 [40786-08-1]. All these drugs reduced the no. of ova released from the treated ovaries in a dose-dependent manner, without affecting ovulation from contralateral ovaries. NDGA was the most potent inhibitor, and its effect cannot be ascribed to its inhibition of ovarian prostaglandin E synthesis. Conversion of labeled arachidonic acid via the lipoxygenase pathway by preovulatory rat follicles was demonstrated by TLC. These results suggest the involvement of products of the lipoxygenase pathway of arachidonic acid in ovulation in the rat. .