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135-51-3

Basic Information
CAS No.: 135-51-3
Name: Disodium 2-naphthol-3,6-disulfonate
Molecular Structure:
Molecular Structure of 135-51-3 (Disodium 2-naphthol-3,6-disulfonate)
Formula: C10H6Na2O7S2
Molecular Weight: 348.265
Synonyms: 2,7-Naphthalenedisulfonicacid, 3-hydroxy-, disodium salt (8CI,9CI);2-Hydroxy-3,6-naphthalenedisulfonicacid disodium salt;2-Naphthol-3,6-disulfonic acid disodium salt;Disodium2-hydroxy-3,6-naphthalenedisulfonate;Fericon;R Salt;
EINECS: 205-196-3
Melting Point: 107oC
Solubility: Soluble in water
Appearance: slightly grey solid
Hazard Symbols: IrritantXi
Risk Codes: 36/38
Safety: 26-36
PSA: 151.39000
LogP: 2.51520
Synthetic route
135-51-3

3-hydroxy-2,7-naphthalenedisulfonic acid disodium salt

3-{4-[(E)-2-(2,4-Dichloro-phenyl)-vinyl]-phenyl}-2-mercapto-4-oxo-3,4-dihydro-quinazoline-6-diazonium

C32H18Cl2N4O8S3(2-)*2Na(1+)

Conditions
ConditionsYield
With sodium carbonate; sodium chloride In water 1.) 0-5 deg C, 3 h; 2.) 60 deg C;82%
1359877-34-1

1-adamantyl-(4-aminophenyl)methanone

135-51-3

3-hydroxy-2,7-naphthalenedisulfonic acid disodium salt

4-(2-(4-(1-adamantylcarbonyl)phenyl)diazenyl)-3-hydroxynaphthalene-2,7-disulfonate disodium

Conditions
ConditionsYield
Stage #1: 1-adamantyl-(4-aminophenyl)methanone With hydrogenchloride; sodium nitrite In water for 0.25h;
Stage #2: 3-hydroxy-2,7-naphthalenedisulfonic acid disodium salt With sodium hydroxide In water for 0.25h;
76%
135-51-3

3-hydroxy-2,7-naphthalenedisulfonic acid disodium salt

sodium 5-aminonaphthalene-1-sulfonate

C20H11N2O10S3(3-)*3Na(1+)

Conditions
ConditionsYield
Stage #1: sodium 5-aminonaphthalene-1-sulfonate With hydrogenchloride; sodium nitrite In water at 0 - 5℃;
Stage #2: 3-hydroxy-2,7-naphthalenedisulfonic acid disodium salt In water at 0 - 5℃; pH=9 - 10;
71%
1359877-36-3

1-adamantyl-(3-aminophenyl)methanone

135-51-3

3-hydroxy-2,7-naphthalenedisulfonic acid disodium salt

4-(2-(3-(1-adamantylcarbonyl)phenyl)diazenyl)-3-hydroxynaphthalene-2,7-disulfonate disodium

Conditions
ConditionsYield
Stage #1: 1-adamantyl-(3-aminophenyl)methanone With hydrogenchloride; sodium nitrite In water for 0.25h;
Stage #2: 3-hydroxy-2,7-naphthalenedisulfonic acid disodium salt With sodium hydroxide In water for 0.25h;
71%
553-26-4

4,4'-bipyridine

cobalt(II) nitrate hexahydrate

135-51-3

3-hydroxy-2,7-naphthalenedisulfonic acid disodium salt

[{Co(4,4’-bipyridine)(H2O)4}.(3-hydroxy-2,7-naphthalenedisulfonate)·2H2O]n

Conditions
ConditionsYield
In methanol at 20℃; for 0.166667h;70%
135-51-3

3-hydroxy-2,7-naphthalenedisulfonic acid disodium salt

Sodium 2-aminonaphthalene-6-sulfonate

C20H11N2O10S3(3-)*3Na(1+)

Conditions
ConditionsYield
Stage #1: Sodium 2-aminonaphthalene-6-sulfonate With hydrogenchloride; sodium nitrite In water at 0 - 5℃;
Stage #2: 3-hydroxy-2,7-naphthalenedisulfonic acid disodium salt In water at 0 - 5℃; pH=9 - 10;
63%
58306-87-9

sodium 2-amino-5-naphthalenesulfonate

135-51-3

3-hydroxy-2,7-naphthalenedisulfonic acid disodium salt

C20H11N2O10S3(3-)*3Na(1+)

Conditions
ConditionsYield
Stage #1: sodium 2-amino-5-naphthalenesulfonate With hydrogenchloride; sodium nitrite In water at 0 - 5℃;
Stage #2: 3-hydroxy-2,7-naphthalenedisulfonic acid disodium salt In water at 0 - 5℃; pH=9 - 10;
62%
135-51-3

3-hydroxy-2,7-naphthalenedisulfonic acid disodium salt

28907-84-8

sodium 5-aminonaphthalene-2-sulfonate

C20H11N2O10S3(3-)*3Na(1+)

Conditions
ConditionsYield
Stage #1: sodium 5-aminonaphthalene-2-sulfonate With hydrogenchloride; sodium nitrite In water at 0 - 5℃;
Stage #2: 3-hydroxy-2,7-naphthalenedisulfonic acid disodium salt In water at 0 - 5℃; pH=9 - 10;
57%
135-51-3

3-hydroxy-2,7-naphthalenedisulfonic acid disodium salt

214360-73-3

4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)aniline

1-(4-boronophenylazo)-2-hydroxy-3,6-naphthalenedisulfonic acid disodium salt

Conditions
ConditionsYield
Stage #1: 4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)aniline With hydrogenchloride; sodium nitrite for 0.25h;
Stage #2: 3-hydroxy-2,7-naphthalenedisulfonic acid disodium salt In water at 0 - 20℃; Further stages.;
33%
Stage #1: 4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)aniline With hydrogenchloride; sodium nitrite In water at 0℃; for 0.5h;
Stage #2: 3-hydroxy-2,7-naphthalenedisulfonic acid disodium salt With sodium hydroxide In water for 0.75h; pH=6;
21.8%
135-51-3

3-hydroxy-2,7-naphthalenedisulfonic acid disodium salt

13954-50-2

3,3'-dimethyl-biphenyl-4,4'-bisdiazonium; dichloride

7585-39-9

β‐cyclodextrin

C42H70O35*C34H22N4O14S4(4-)*4Na(1+)

Conditions
ConditionsYield
With sodium carbonate6%
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  • 3-Hydroxy-2,7-Naphthalenedisulfonic Acid, Disodium Salt

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Chemistry


IUPAC Name: Disodium 3-hydroxynaphthalene-2,7-disulfonate
Canonical SMILES: C1=CC(=CC2=CC(=C(C=C21)O)S(=O)(=O)[O-])S(=O)(=O)[O-].[Na+].[Na+]
InChI: InChI=1S/C10H8O7S2.2Na/c11-9-4-6-1-2-8(18(12,13)14)3-7(6)5-10(9)19(15,16)17;;/h1-5,11H,(H,12,13,14)(H,15,16,17);;/q;2*+1/p-2
Empirical Formula: C10H6Na2O7S2 
Molecular Weight: 348.26 
EINECS: 205-196-3
Classification Code: Reproductive Effect
Stability: Stable. Incompatible with strong oxidizing agents.
H-Bond Donor: 1  
H-Bond Acceptor of R salt (CAS NO.135-51-3): 7

Uses

 R salt (CAS NO.135-51-3) is used for the system of food coloring, azo dyes, photosensitive copying paper. It is used as a fluorescent indicator, but also for the synthesis of azo dyes and used for the production of edible pigment, azo dyes, photosensitive copy paper.

Consensus Reports

Reported in EPA TSCA Inventory.

Safety Profile

An experimental teratogen. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of SOx and Na2O.
Hazard Codes: IrritantXi
Risk Statements:
R36/38:Irritating to eyes and skin .
Safety Statements:
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing .
WGK Germany: 3
RTECS: QJ6477000 

Specification

  R salt (CAS NO.135-51-3), its Synonyms are 2-Naphthol-3,6-disulfonic acid sodium salt ; 2-Naphthol-3,6-disulfonic acid, disodium salt ; 3-Hydroxy-2,7-naphthalenedisulfonic acid disodium salt ; 3-Hydroxynapthlene-2,7-disulfonic acid sodium salt ; Disodium 2-hydroxy-3,6-naphthalene disulfonate ; Disodium 2-naphthol-3,6-disulfonate ; Fericon ; Ferricon ; 2,7-Naphthalenedisulfonic acid, 3-hydroxy-, disodium salt ; 2,7-Naphthalenedisulfonic acid, 3-hydroxy-, sodium salt (1:2) . It is slightly grey solid.