Detail of "13551-92-3"

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Sensitization of normal and malignant tissues to cyclophosphamide by nitroimidazoles with different partition coefficients

Sensitization of normal and malignant tissues to cyclophosphamide by nitroimidazoles with different partition coefficients. Hirst, D. G.; Hazlehurst, J. L.; Brown, J. 50-18-0 and 13551-87-6 are also occured in this study. M. (Dep. Radiol., Stanford Univ., Stanford, CA 94305, USA). Br. J. Cancer, 49(1), 33-42 (English) 1984. CODEN: BJCAAI. ISSN: 0007-0920. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Section cross-reference(s): 8 The ability of a range of 2-nitroimidazoles with similar electron affinities but widely differing partition coeffs. to enhance the cytotoxicity of cyclophosphamide (CY) [50-18-0] in mouse tumor and normal tissues was investigated. Large single doses of benznidazole [22994-85-0], misonidazole (MISO) [13551-87-6], demethylmisonidazole [13551-92-3], and SR-2508 [22668-01-5] enhanced the sensitivity of RIF-1 and SCC VII/St tumors similarly. SR-2555 [74141-74-5] was less effective. A direct comparison was made between MISO and SR-2508 by using prolonged, low-level drug exposures, achieved by multiple injections. The enhancement of CY cytotoxicity achieved in the 2 tumor systems was similar for a given blood concn. of sensitizer. In the normal tissue assays (white blood cell count, bone marrow CFU-S and testis spermatogonia) neither MISO nor SR-2508 enhanced CY cytotoxicity, so that the therapeutic gains achieved at a given blood concn. of sensitizer were similar for SR-2508 and MISO. The main advantage of SR-2508, however, probably lies in its lower toxicity, permitting higher blood levels to be achieved. However, the slopes of the dose-response curves are rather shallow, so a dramatically increased benefit cannot be predicted. .

Primary cell cultures initiated from adult mouse dorsal root ganglia as a system for neurotoxicity screening

Primary cell cultures initiated from adult mouse dorsal root ganglia as a system for neurotoxicity screening. Smith, R. A.; McInnes, I. B. (Dep. Anat., Univ. Glasgow, Glasgow G12 8QQ, UK). Food Chem. Toxicol., 24(6-7), 581-2 (English) 1986. CODEN: FCTOD7. ISSN: 0278-6915. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Section cross-reference(s): 4 A system based on cultures derived from adult mouse dorsal root ganglia and monitored for up to 6 wk by phase contrast and electron microscopy is being studied as a possible means of identifying neurotoxic agents. Enzyme treatment is used to reduce the mech. disruption required for cell sepn. In a pilot study on nitroimidazoles [misonidazole (I) [13551-87-6] and demethylmisonidazole [13551-92-3]], the morphol. changes indicate that these primary cultures may be useful in the monitoring of potential neurotoxins.