Detail of "13590-98-2"
- CAS Number:
- 13590-98-2
- Name:
Imidodicarbonimidic diamide,N,N'-bis(4-chlorophenyl)-,monohydrochloride
Imidodicarbonimidic diamide,N,N'-bis(4-chlorophenyl)-,monohydrochloride
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Reference
- A screening method depending on protein folding for identifying potential pharmaceutical ligands for target proteins
- A screening method depending on protein folding for identifying potential pharmaceutical ligands for target proteins. Pakula, Andrew; Bowie, James (Scriptgen Pharmaceuticals, Inc., USA). Eur. Pat. Appl. EP 770876 A1 2 May 1997, 32 pp.Several reagents such as 13590-98-2 is used here. DESIGNATED STATES: R: AT, BE, CH, DE, DK, ES, FI, FR, GB, GR, IE, IT, LI, LU, MC, NL, PT, SE. (English). (European Patent Organization). CODEN: EPXXDW. CLASS: ICM: G01N033-68. ICS: G01N033-543. ICA: C12Q001-37. APPLICATION: EP 1996-610042 17 Oct 1996. PRIORITY: US 1995-547889 25 Oct 1995. DOCUMENT TYPE: Patent CA Section: 1 (Pharmacology) A method for screening chem. compds. (test ligands) for potential pharmaceutical effectiveness is provided. The method identifies possible therapeutic test ligands by placing them in the presence of target proteins and detg. their ability to increase or decrease the ratio of folded target protein to unfolded target protein. The present methods do not require that biochem. function of the target protein be known, nor that any other ligands be previously identified. The methodol. of the invention was used to identify ligands. e.g. inhibiting Hb S polymn. .