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Detail of "13647-35-3"

  • CAS Number:
  • 13647-35-3
  • Name:

  • Trilostane

  • Molecular Structure:
  • Formula:
  • C20H27NO3
  • Molecular Weight:
  • 329.48
  • Deleted CAS:
  • 28414-46-2|27107-98-8
  • Synonyms:
  • Desopan;Modrastane;Modrefen;Modrenal;5-alpha-Androstane-2-alpha-carbonitrile, 4-alpha,5-epoxy-17-;Vetoryl;Win 24540;(2-alpha,4-alpha,5-alpha,17-beta)-4,5-Epoxy-17-hydroxy-3-;
  • EINECS:
  • 237-133-0
  • Density:
  • 1.25 g/cm3
  • Melting Point:
  • 264 °C
  • Boiling Point:
  • 497.8 °C at 760 mmHg
  • Flash Point:
  • 254.8 °C
  • Appearance:
  • tan crystals
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CAS No.13647-35-3 TrilostaneCompetitive Product

Trilostane

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CAS No.13647-35-3 Trilostane

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Trilostane,Cas#13647-35-3

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CAS No.13647-35-3 Trilostane

Desopan; Modrastane; Modrefen; Modrenal; Trilostane; Vetoryl; Win 24540

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CAS No.13647-35-3 Trilostane

Assay:99%min

Product: Trilostane Use: Cushing's disease in dogs Product Name: Trilostane Synonyms: TRILOSTANE;(2-alpha,4-alpha,5-alpha,17-beta)-4,5-epoxy-17-hydroxy-3-oxoandrostane-2-car;17-beta)-ph;4-alpha,5-epoxy-17-beta-hydroxy-3-oxo-5-alpha-androstane-2-alpha-carbonitril;4-alpha,5

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CAS No.13647-35-3 Trilostane

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Product Name: Trilostane Synonyms: (4a,5a,17b)-3,17-Dihydroxy-4,5-epoxyandrost-2-ene-2-carbonitrile Molecular Formula: C20H27NO3 Molecular Weight: 329.43 Specific optical rotation:+137~+139 Melting point: 257~270 degree Content: not less than 99.0% (HPLC) Loss on drying:

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CAS No.13647-35-3 Trilostane

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Product name :Trilostane CBNumber: CB4768762 MF: C20H27NO3 MW: 329.43 MOL: Mol file

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Trilostane is an inhibitor of 3 β-hydroxysteroid dehydrogenase used in the treatment of Cushing's syndrome.

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Reference

Induction of transient functional luteolysis in cyclic sheep by a 3b-hydroxysteroid dehydrogenase inhibitor
Induction of transient functional luteolysis in cyclic sheep by a 3b-hydroxysteroid dehydrogenase inhibitor. Jenkin, G.; Gemmell, R. T.; Thorburn, G. D. (Dep. Physiol. Pharmacol., Univ. Queensland, St. Lucia 4067, Australia). J. Endocrinol., 100(1), 61-6 (English) 1984. CODEN: JOENAK. ISSN: 0022-0795. DOCUMENT TYPE: Journal CA Section: 2 (Mammalian Hormones) Section cross-reference(s): 7 The effect of trilostane [13647-35-3], a 3b-hydroxysteroid dehydrogenase (3b-HSD) [9015-81-0] inhibitor, on luteal function and morphol. was investigated in ewes. Injection of trilostane i.v. in the mid-luteal phase of the estrous cycle decreased ovarian tissue progesterone [57-83-0] content. A transient decrease in peripheral and uteroovarian vein plasma progesterone was obsd. 57-83-0 and 27376-76-7 which are cas registry numbers of chemicals are mentioned. but there was no effect on the length of the luteal phase of the cycle. There was no change in plasma 13,14-dihydro-15-oxo-prostaglandin F2a [27376-76-7] during the period when plasma progesterone was depressed. Morphol. examn. of the corpora lutea revealed a decreased concn. of electron-dense granules without any other features of impending luteal regression. When plasma progesterone was reduced for >10 h by 2 injections of trilostane 4 h apart, there was again no subsequent effect on the length of the estrous cycle or on the return to estrus. Plasma progesterone returned to preinjection levels within 24 h of injection. Apparently, competitive inhibition of 3b-HSD activity, is ineffective in bringing about structural luteolysis. .
Study on steroidogenesis in ova
Study on steroidogenesis in ova. Endo, Yoshihiro (Sch. Med., Keio Univ., Tokyo, Japan). Nippon Funin Gakkai Zasshi, 29(1), 54-61 (Japanese) 1984.Several substances with their cas registry numbers 9002-61-3 and 9044-85-3 may be metioned in this study. CODEN: NFGZAD. ISSN: 0029-0629. DOCUMENT TYPE: Journal CA Section: 2 (Mammalian Hormones) An indirect immunofluorescence study of steroidogenesis in the ova showed (1) the presence of endogenous progesterone [57-83-0], 17b-estradiol (I) [50-28-2], and D5-3b-hydroxysteroid dehydrogenase (II) [9044-85-3] in human follicular oocytes; (2) the presence of endogenous I and the activity of II in hamster follicular and ovulated ova; (3) inhibition of the activity of II in hamster follicular and ovulated ova by preincubation with human chorionic gonadotropin [9002-61-3] in vitro; and (4) inhibition of the activity of II in hamster ovulated ova by preincubation with trilostane [13647-35-3] in a dose-dependent manner. The role of steroidogenesis in oocyte maturation and subsequent fertilization is discussed. .
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