Detail of "13707-88-5"

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CAS Number:
13707-88-5
Name:
2-Propanol,1-[(1-methylethyl)amino]-3-[2-(2-propen-1-yl)phenoxy]-, hydrochloride (1:1)
Molecular Structure:
Formula:
C15H23 N O2 . Cl H
Molecular Weight:
285.85
Synonyms:
2-Propanol,1-(o-allylphenoxy)-3-(isopropylamino)-, hydrochloride (8CI); 2-Propanol,1-[(1-methylethyl)amino]-3-[2-(2-propenyl)phenoxy]-, hydrochloride (9CI); (?à)-1-(o-Allylphenoxy)-3-isopropylamino-2-propanolhydrochloride; (?à)-Alprenololhydrochloride; 1-(2-Allylphenoxy)-2-hydroxy-3-isopropylaminopropanehydrochloride; 1-(o-Allylphenoxy)-3-(isopropylamino)-2-propanol hydrochloride;Alfeprol; Alprenolol hydrochloride; Apllobal; Applobal; Aprobal; Aptin; Aptine;Aptol Duriles; Betaptin; DL-1-(o-Allylphenoxy)-3-isopropylamino-2-propanolhydrochloride; Dimacor; Gubernal; H 56/28; Regletin; Yobir; dl-Alprenololchloride
EINECS:
237-244-4
Density:
1.007g/cm³
Melting Point:
108°C to 112°C.
Boiling Point:
383.4 °C at 760 mmHg
Flash Point:
185.7 °C
Solubility:
H2O: 50 mg/mL in water
Hazard Symbols:
Xn
Risk Codes:
22
Safety:
Poison by ingestion, subcutaneous, intravenous and intraperitoneal routes. Human systemic effects by ingestion: change in heart rate. When heated to decomposition it emits very toxic fumes of HCl and NO_x. See also ALLYL COMPOUNDS. Details

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Alprenolol Hydrochloride

Supplier:Spectrum China Ltd. [ China (Mainland)]

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Tel:+86-21-67601368

Address:3802 Shen Gang Rd. Bldg C3 & A20 Song Jiang District, Shanghai, China 201611

ALPRENOLOL HYDROCHLORIDE

Supplier:Waterstone Technology, LLC [ United States]

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Tel:+1-317 644 0862

Address:12202 Hancock St. Carmel, IN 46032

2-CHLORO-3-NITROTHIOPHENE-5-SULFONAMIDE

Supplier:Leap Labchem Co.,Ltd [ China (Mainland)]

610 Integral
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Tel:+86-571-87756549

Address:316 JiaoGong Road HangZhou City,ZheJiang China

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Effect of: Effect of .beta.-blocking agents and angiotensin II on isoproterenol-stimulated renin release from rat kidney slices. Capponi, Alessandro M.; Gourjon, Martine; Vallotton, Michel B. (Fac. Med., Univ. Geneva, Geneva, Switz.). Circ. Res., Suppl., (1), 89-93 (English) 1977. CODEN: CIRSAF. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) Section cross-reference(s): 2 Metoprolol tartrate [55250-54-9], acebutolol-HCl [34381-68-5], labetalol-HCl [32780-64-6], and d-propranolol-HCl [13071-11-9] (10-8-10-5M) had no effect on isoproterenol-stimulated renin [9015-94-5] release from rat kidney slices, whereas pindolol [21870-06-4] and bufuralol [54340-62-4] demonstrated min. inhibition at 10-5M. Isoproterenol stimulation was completely inhibited when dl-propranolol-HCl [3506-09-0] or l-propranolol-HCl [4199-10-4], alprenolol-HCl [13707-88-5], and sotalol-HCl [959-24-0] were administered at doses ranging between 5 .times. 10-6 and 10-6M. Dose-related inhibition was obsd. with practolol [6673-35-4], oxprenolol-HCl [6452-73-9], timolol maleate [26921-17-5], nadolol [42200-33-9], and atenolol [29122-68-7] (10-8-10-5M). Basal renin release was inhibited by 10-6M angiotensin II [11128-99-7] which also inhibited isoproterenol-stimulated renin release. (Sar1, Ala8) angiotensin II [11130-03-3] had no direct effects on either basal or isoproterenol-stimulated renin release, but blocked the inhibitory action of angiotensin II on these parameters.

Effect of pentobarbital on the disposition of alprenolol: Effect of pentobarbital on the disposition of alprenolol. Alvan, Gunnar; Piafsky, Kenneth; Lind, Margareta; Von Bahr, Christer (Karolinska Inst., Huddinge Univ. Hosp., Huddinge, Swed.). Clin. Pharmacol. Ther., 22(3), 316-21 (English) 1977. CODEN: CLPTAT. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) Alprenolol-HCl (I-HCl) [13707-88-5] was administered orally and i.v. to 5 healthy subjects before and after 10 to 14 daily doses of 0.1 g Mebumal (pentobarbital) [57-33-0]. The area under the plasma concn. time curve after an oral 200-mg dose decreased from 706 to 154 ng/mL/h (mean and SD) with the barbiturate treatment, but there was no change in elimination rate. The change in area corresponded to an increase in extn. by the liver from 0.72 to 0.93. The disposition of a 5.0-mg i.v. dose of I did not change after pentobarbital treatment. There was no indication of a marked change in hepatic blood flow estd. from the clearance of I after i.v. administration. Thus, pentobarbital administration induces the metab. of I in man and the pharmacokinetic theories derived for hepatic extn. of drugs subject to a high metabolic clearance can be successfully applied.