Detail of "13710-19-5"

Reference

Effect of gastric pH on antidotal efficacy of activated charcoal in man

Effect of gastric pH on antidotal efficacy of activated charcoal in man. Olkkola, K. T.; Neuvonen, P. J. (Dep. Clin. Pharmacol., Univ. Helsinki, Helsinki SF-00250, Finland). Int. J. Clin. Pharmacol., Ther. Toxicol., 22(10), 565-9 (English) 1984. CODEN: IJCPB5. ISSN: 0300-9718. DOCUMENT TYPE: Journal CA Section: 4 (Toxicology) Section cross-reference(s): 1, 63 The influence of gastric acidity was examd. on the antidotal efficacy of orally administered activated charcoal in humans. The gastric pH was regulated by the administration of Mg(OH)2 prior to the ingestion of acidic drugs aspirin [50-78-2] and tolfenamic acid [13710-19-5] and basic drug disopyramide [3737-09-5]. The activated charcoal (2.5 g) administered immediately after the drugs, decreased the absorption of aspirin by 30-40% and of the other 2 drugs by 70-80%. The antacid had no effect on the inhibition of absorption. Under in vitro studies the unabsorbed fraction of aspirin and disopyramide were increased by 10-20-fold as the pH was raised from 1.2 to 7.0. The gastric pH presumably had no effect on the antidotal efficacy of charcoal.

Do gastric contents modify antidotal efficacy of oral activated charcoal?

Do gastric contents modify antidotal efficacy of oral activated charcoal?. Olkkola, K. T.; Neuvonen, P. J. (Dep. Clin. Pharmacol., Univ. Helsinki, Helsinki SF-00250, Finland). Br. J. Clin. Pharmacol., 18(5), 663-9 (English) 1984. CODEN: BCPHBM. ISSN: 0306-5251. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Section cross-reference(s): 4 The effect of food on the antidotal efficacy of activated charcoal was studied in 6 healthy volunteers who ingested aspirin [50-78-2] (1000 mg), mexiletine [31828-71-4] (200 mg), and tolfenamic acid [13710-19-5] (400 mg) in a randomized cross-over study. Activated charcoal 25 g, suspended in water, was administered 5 min or 60 min after the drugs were taken on an empty stomach or after a std. meal. The serum concns. and the cumulative excretion into urine of the drugs were followed for 48 h. When the drugs were taken on an empty stomach, activated charcoal given 5 min or 60 min afterwards reduced the bioavailability of the drugs by 75-98% or 10-60%, resp. Food moderately weakened the effect of activated charcoal administered 5 min after the drugs, but when the charcoal was given 1 h later, the effect was still practically the same, the redn. of adsorption varying in both cases in the range of 45-85%. Thus, the efficacy of charcoal given 60 min after the drugs was better after a std. meal than on an empty stomach. Presence of food in the stomach of patients with drug overdosage modifies the efficacy of activated charcoal and gives it more time to adsorb drugs in the gastrointestinal canal, possibly by slowing gastric emptying rate.