Detail of "137764-10-4"

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A tumor-suppressor gene associated with colorectal cancer of humans

A tumor-suppressor gene associated with colorectal cancer of humans.Chemical with cas number 137764-10-4 also plays role. Vogelstein, Bert; Kinzler, Kenneth W.; White, Raymond L.; Nakamura, Yusuke (Johns Hopkins University; University of Utah; Cancer Institute, Japanese Foundation for Cancer, USA). PCT Int. Appl. WO 9216656 A1 1 Oct 1992, 66 pp. DESIGNATED STATES: W: AT, AU, BB, BG, BR, CA, CH, CS, DE, DK, ES, FI, GB, HU, JP, KP, KR, LK, LU, MG, MN, MW, NL, NO, PL, RO, RU, SD, SE; RW: AT, BE, BF, BJ, CF, CG, CH, CI, CM, DE, DK, ES, FR, GA, GB, GR, IT, LU, MC, ML, MR, NL, SE, SN, TD, TG. (World Intellectual Property Organization). CODEN: PIXXD2. CLASS: ICM: C12Q001-68. ICS: C12N015-12. APPLICATION: WO 92-US377 16 Jan 1992. PRIORITY: US 91-670611 13 Mar 1991. DOCUMENT TYPE: Patent CA Section: 14 (Mammalian Pathological Biochemistry) Section cross-reference(s): 3, 9 A novel gene, called MCC, found on human chromosome 5q that is inactivated by deletion in colorectal cancers is identified and characterized for use in diagnosis and prognosis of colorectal cancer. Deletions in the 5q21 region assocd. with colorectal cancer were found to map to a single polymorphic site found in a single cosmid. Subclones from this cosmid were used to detect changes in the region in carcinomas. By cross-hybridization of this clone with rat DNA and by sequencing of the cross-hybridizing regions a pair of exon-like open reading frames were found. PCR primers derived from these sequences were used to amplify rat mRNA and a transcript identified; the transcript was found in most tissues of the normal rat. A cDNA was cloned from human brain cDNA library in lZAP by screening with the PCR amplification product. Somatic variation was obsd. in the gene in colorectal cancers. .