Detail of "138-39-6"

CAS Number:
138-39-6
Name:
Benzenesulfonamide,4-(aminomethyl)-
Molecular Structure:
Formula:
C₇H₁₀N₂O₂S
Molecular Weight:
186.23
Synonyms:
p-Toluenesulfonamide,a-amino- (8CI);4-(Aminomethyl)benzenesulfonamide;4-(Aminosulfonyl)benzylamine;4-Homosulfanilamide;4-Sulfamoylbenzylamine;Ambamide;Benzamsulfonamide;Emilene;Homonal;Homosul;Homosulfanilamide;Mafenide;Malfamin;Maphenid;Maphenide;Marprontil;Mesudin;Mesudrin;NSC 34632;Neofamid;Paramenyl;Septicid;Sulfamylon;p-(Aminomethyl)benzenesulfonamide;p-Sulfamoylbenzylamine;a-Amino-p-toluenesulfonamide;
EINECS:
205-326-9
Density:
1.345 g/cm³
Boiling Point:
382 °C at 760 mmHg
Flash Point:
184.8 °C

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Treating burns: Treating burns. Schmitt, Edward E. (Alza Corp., USA). U.S.Chemicals with cas numbers 61128-29-8 and 9002-01-1 also play role. US 3983209 28 Sep 1976, 6 pp. (English). (United States of America). CODEN: USXXAM. CLASS: IC: A61K031-74. NCL: 424078000. APPLICATION: US 75-544807 28 Jan 1975. DOCUMENT TYPE: Patent CA Section: 63 (Pharmaceuticals) Burns are treated by contacting the burned surface with a compn. contg. a bactericide, antibiotic, fungicide, or proteolytic enzyme in a bioerodible polymer such as poly(2,2-dioxahexamethylene tetrahydrofuran) (I) [61128-29-8]. The polymer on bioerosion releases an effective amt. of active ingredient to the burn; e.g., in a group of 5 rats with burned skin and induced Pseudomonas aeruginosa infection, no rats died when treated with a polyester double knit fabric impregnated with a mixt. of 10% 4-homosulfanilamide [138-39-6] homogeneously dispersed in 90% I. In a group of 5 receiving the polyester impregnated with prior art Sulfamylon, one rat died 11 days postburn. In a control group receiving only polyester fabric 1 died 9 days postburn and another 11 days postburn. .

Studies on the phosphorimetric determination of amines with halonitrocompounds: Studies on the phosphorimetric determination of amines with halonitrocompounds. I. Phosphorimetric determination of 4-homosulfanilamide with 4-fluoronitrobenzene. Hirauchi, Kazumasa; Amano, Tameyuki (Shionogi Res. Lab., Shionogi and Co., Ltd., Osaka, Japan). Chem. Pharm. Bull., 25(6), 1326-9 (English) 1977. CODEN: CPBTAL. DOCUMENT TYPE: Journal CA Section: 64 (Pharmaceutical Analysis) 4-Homosulfanilamide (I) [138-39-6] reacted with 4-fluoronitrobenzene (II) [350-46-9] to form N4-(4-nitrophenyl)-4-sulfamoylbenzylamine [63949-12-2], which strongly phosphoresced in 9:1 EtOH-DMSO. This observation was successfully used to det. microamts. of I. A linear relation between the phosphorescence intensity and amine concn. was obsd. in the range of 2 .times. 10-6-2 .times. 10-4M. This phosphorimetric method was 5-25 times more sensitive than colorimetric methods.