Reference

The mutagenic and cell transforming properties of shikimic acid and some of its bacterial and mammalian metabolites

The mutagenic and cell transforming properties of shikimic acid and some of its bacterial and mammalian metabolites.Some chemicals with cas registry numbers like 120-80-9 and 98-89-5 are also used. Jones, R. S.; Ali, M.; Ioannides, C.; Styles, J. A.; Ashby, J.; Sulej, J.; Parke, D. V. (Dep. Biochem., Univ. Surrey, Guildford GU2 5XH, UK). Toxicol. Lett., 19(1-2), 43-50 (English) 1983. CODEN: TOLED5. ISSN: 0378-4274. DOCUMENT TYPE: Journal CA Section: 4 (Toxicology) Known and proposed metabolites of shikimic acid (I) [138-59-0] were synthesized, characterized, and tested for genotoxic activity using the Salmonella/mammalian microsome mutagenicity test, the bacterial fluctuation mutagenicity test, and the BHK 21 cell transformation test. Under the conditions used, none of these compds. showed activity. However, I itself was active in the BHK 21 cell transformation assay. It therefore seems unlikely that I is a neoplasm-initiating agent, but I may act as a carcinogen-promoting agent in the bracken fern (Pteridium aquilinum). .

Effects of glyphosate on caffeic acid metabolism in Perilla cell suspension cultures

Effects of glyphosate on caffeic acid metabolism in Perilla cell suspension cultures. Ishikura, Nariyuki; Takeshima, Yasunobu (Fac. Sci., Kumamoto Univ., Kumamoto 860, Japan). Plant Cell Physiol., 25(1), 185-9 (English) 1984. CODEN: PCPHA5.There are some reagents with their cas registry numbers 331-39-5 and 1071-83-6 are used in this study. ISSN: 0032-0781. DOCUMENT TYPE: Journal CA Section: 5 (Agrochemical Bioregulators) Section cross-reference(s): 11 Perilla Cell suspension cultures contained caffeic acid [331-39-5] at 0.073% of the fresh wt. When 1 mM glyphosate [1071-83-6] was administered to the cell culture in the logarithmic and stationary phases, the amt. of caffeic acid ceased to increase and remained at a nearly const. level during the following several days. Phenylalanine ammonia-lyase (PAL) [9024-28-6] activity in the cell culture increased immediately after transfer to a fresh medium, decreased rapidly in the midst of the logarithmic phase and became almost undetectable in the stationary phase. PAL activity was markedly inhibited by glyphosate at >0.2 mM. The shikimic acid [138-59-0] content of cells from 14-day culture grown in the presence of 1 mM glyphosate increased ￡74.9 mg/g during 6-day culture, whereas that of the control cells was undetectable. The dosage of 0.15 mM L-2-aminooxy-3-phenylpropionic acid [42990-62-5], an inhibitor of PAL, to the cells did not cause shikimic acid accumulation. .