Detail of "138071-82-6"

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Neurotoxicity of gadolinium contrast agents for magnetic resonance imaging in rats with osmotically disrupted blood-brain barrier

Neurotoxicity of gadolinium contrast agents for magnetic resonance imaging in rats with osmotically disrupted blood-brain barrier. Takahashi, Masaya; Tsutsui, Hirokazu; Murayama, Chie; Miyazawa, Tomoaki; Fritz-Zieroth, Bernhard (Research Department, Yodogawa 532, Japan). Magnetic Resonance Imaging, 14(6), 619-623 (English) 1996 Elsevier. CODEN: MRIMDQ. ISSN: 0730-725X. DOCUMENT TYPE: Journal CA Section: 8 (Radiation Biochemistry) The neurotoxicity of i.v. injected Gadolinium (Gd) complexes to rats with disrupted blood-brain barrier (BBB) was evaluated. After disruption of the BBB by infusion of mannitol soln., one of several contrast agents tested was injected i.v. at a dose of 1 or 3 mmol Gd/kg, and neurol. symptoms were graded. The concns. of Gd in brain and plasma were also measured. Injection of Gd-DTPA at a dose of 3 mmol Gd/kg did not change behavior. On the other hand, Gd-DTPA-BMA, Gd-DO3A-butrol, and Gd-DO3A-HP each induced behavioral impairments, and some animals died within 1 h after injection. Gd-DO3A-HP showed lethal effect even at a dose of 1 mmol/kg. The concn. of Gd in the brain of the animals injected with Gd-DO3A-HP at 3 mmol Gd/kg was essentially the same as that of animals injected with Gd-DTPA at the same dose. 138071-82-6 and 131410-48-5 are just another two chemicals used in this study. The neurotoxicity of the contrast agents tested was graded as follows: Gd-DTPA ￡ Gd-DTPA-BMA = Gd-DO3A-butrol < Gd-DO3A-HP. .