Reference

Industrial-scale aromatization process for the manufacture of 2-(7-methoxy-1-naphthyl)acetonitrile an intermediate in the synthesis of agomelatine

Souvie, Jean-Claude; Gonzalez Blanco, Isaac (Les Laboratoires Servier, Fr.). Eur.Some chemicals with cas registry numbers like 138113-08-3 are also used. Pat. Appl. EP 1564205 A1 17 Aug 2005, 7 pp. DESIGNATED STATES: R: AT, BE, CH, DE, DK, ES, FR, GB, GR, IT, LI, LU, NL, SE, MC, PT, IE, SI, LT, LV, FI, RO, MK, CY, AL, TR, BG, CZ, EE, HU, PL, SK, BA, HR, IS, YU. (French). (European Patent Organization). CODEN: EPXXDW. CLASS: ICM: C07C253-30. APPLICATION: EP 2005-290310 11 Feb 2005. PRIORITY: FR 2004-1437 13 Feb 2004. DOCUMENT TYPE: Patent CA Section: 25 (Benzene, Its Derivatives, and Condensed Benzenoid Compounds) Section cross-reference(s): 45 2-(7-Methoxy-1-naphthyl)acetonitrile, an intermediate in the prepn. of agomelatine, is prepd. in high yield and selectivity by the aromatization, in toluene, of the precursor compd. 2-(7-methoxy-3,4-dihydro-1-naphthyl)acetonitrile with both a hydrogenation catalyst (e.g., Pd/C) and an allylic compd.(e.g., allyl methacrylate). .