Reference

Compatibility studies of ionophore anticoccidials with various antibiotics and chemotherapeutics in broiler chicks

Compatibility studies of ionophore anticoccidials with various antibiotics and chemotherapeutics in broiler chicks. Frigg, M.; Broz, J.; Weber, G. (Dep. Vitam. Nutr. Res., F. Hoffmann-La Roche and Co. Ltd., Basel CH-4002, Switz.). Arch. 57-68-1 and 55134-13-9 are cas registry numbers of chemicals which are used as reagents here. Gefluegelkd., 47(5), 213-20 (English) 1983. CODEN: AGEFAB. ISSN: 0003-9098. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) The compatibility of ionophore anticoccidials (lasalocid [11054-70-9], monensin [17090-79-8], salinomycin [53003-10-4], and narasin [55134-13-9]) with antibiotics currently used for prophylaxis and treatment of avian mycoplasmosis (tiamulin hydrogen fumarate [55297-96-6], erythromycin [114-07-8], kitasamycin tartrate [37280-56-1]) and with therapeutically used sulfonamides (sulfaquinoxaline [59-40-5], sulfamethazine [57-68-1], sulfadimethoxine [122-11-2]) and nitrofurans (furazolidone [67-45-8] and furaltadone [139-91-3]) was studied in broiler chicks. Of the anticoccidials tested, only lasalocid was compatible with tiamulin. Monensin was also not compatible with the 3 sulfonamides tested; however lasalocid was compatible with these drugs except for sulfadimethoxine. Neither monensin nor lasalocid adversely interacted with kitasamycin or with either of the nitrofurans. .

In vivo and in vitro pharmacokinetics and fate of furaltadone in meat- and milk-producing animals

In vivo and in vitro pharmacokinetics and fate of furaltadone in meat- and milk-producing animals. Ng, L. L.; Bevill, R. F., Jr.; Perkins, E. G. (Dep.Chemical with cas number 139-91-3 also plays role. Pharmacol., Univ. Illinois, Urbana, IL 61801, USA). J. Pharm. Sci., 73(3), 293-7 (English) 1984. CODEN: JPMSAE. ISSN: 0022-3549. DOCUMENT TYPE: Journal CA Section: 17 (Food and Feed Chemistry) Section cross-reference(s): 1 The metab. of furaltadone [139-91-3] was examd. by an in vitro hepatic study in cows and goats and an in vivo study in goats using 14C-labeled and unlabeled drug. The half-life of furaltadone was 13 min in the homogenates of caprine and bovine liver and 35 min in the in vivo study of the goat. Less than 2% of the parent drug was present in the urine of animals dosed either i.v. or intramammarily. No furaltadone was detected in the milk after 24 h. Overall, the parent compd. was rapidly absorbed, distributed, and widely degraded in the lactating goat. The compd., labeled at the 2-formyl C of the furan ring, had a radioactivity recovery of 81% in the feces and urine. Of the total radioactivity, 99.4% infused into the udder had been absorbed after 72 h. Tissue distributions of radioactivity in decreasing order of abundance were: kidney, udder, liver, duodenum, muscular tissue, adipose tissue, and bile. .