CAS No.13909-09-6,SEMUSTINE Suppliers,MSDS download

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Basic Information

Molecular Structure:
CAS No.:	13909-09-6
Name:	SEMUSTINE
Article Data:	2

Formula:	C₁₀H₁₈ClN₃O₂
Molecular Weight:	247.725
Synonyms:	Urea,1-(2-chloroethyl)-3-(4-methylcyclohexyl)-1-nitroso- (8CI);ICIG 1110;Me-CCNU;Methyllomustine;Methyl-CCNU;N-(2-Chloroethyl)-N'-(4-methylcyclohexyl)-N-nitrosourea;N'-(4-Methylcyclohexyl)-N-(2-chloroethyl)-N-nitrosourea;Semustine;
Density:	1.315 g/cm³
Melting Point:	64°C (rough estimate)
Appearance:	Light yellow powder
Hazard Symbols:	T
Risk Codes:	45-46-23/24/25-36/37/38
Safety:	53-22-26-36/37/39-45
Transport Information:	UN 3249
PSA:	61.77000
LogP:	2.88780

Total:23 Page 1 of 1 1

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Chemistry

IUPAC Name: 1-(2-Chloroethyl)-3-(4-methylcyclohexyl)-1-nitrosourea
The MF of Semustine (CAS NO.13909-09-6) is C₁₀H₁₈ClN₃O₂.

The MW of Semustine (CAS NO.13909-09-6) is 247.72.
Synonyms of Semustine (CAS NO.13909-09-6): Urea, N-(2-chloroethyl)-N'-(4-methylcyclohexyl)-N-nitroso- ; 1-trans-(2-Chloroethyl)-3-(4-methylcyclohexyl)-1-nitrosourea ; 1-(2-Choroethyl)-3-(4-methylcyclohexyl)-1-nitrosourea
Apperance: Light yellow powder
Index of Refraction: 1.575
Density: 1.31 g/ml

Uses

Semustine (CAS NO.13909-09-6) is used for stomach cancer, colon cancer, brain cancer, lung cancer, liver cancer, lymphoma, malignant melanoma, and so on.

Toxicity Data With Reference

1.	skn-rbt 5 mg/24H rns	TXCYAC Toxicology. 14 (1979),117.
2.	mmo-sat 100 nmol/plate	JJIND8 JNCI, Journal of the National Cancer Institute. 65 (1980),149.
3.	mma-sat 100 nmol/plate	JJIND8 JNCI, Journal of the National Cancer Institute. 65 (1980),149.
4.	dnd-esc 50 µmol/L	MUREAV Mutation Research. 89 (1981),95.
5.	dni-mus:oth 10 µmol/L	CNREA8 Cancer Research. 43 (1983),5837.
6.	orl-hmn TDLo:22 mg/kg/60W-C:CAR	NEJMAG New England Journal of Medicine. 309 (1983),1079.
7.	ipr-rat TDLo:30 mg/kg/7W-I:CAR	CANCAR Cancer. 40 (Suppl 4)(1977),1935.
8.	orl-hmn TDLo:90 mg/kg:BLD,GIT	CCYPBY Cancer Chemotherapy Reports, Part 3. 4 (1973),257.
9.	orl-hmn TDLo:6 mg/kg:GIT,BLD	CTRRDO Cancer Treatment Reports. 60 (1976),709.
10.	orl-chd LDLo:5550 mg/kg/30W-I	NEJMAG New England Journal of Medicine. 300 (1979),1200.
11.	orl-chd TDLo:37,950&

Consensus Reports

NTP 10th Report on Carcinogens. IARC Cancer Review: Group 1 IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 7 , 1987,p. 150.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Animal Limited Evidence 7,150,87; Human Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 7 , 1987,p. 150.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) . NCI Carcinogenesis Studies (ipr); Clear Evidence: rat CANCAR Cancer. 40 (1977),1935. ; No Evidence: mouse CANCAR Cancer. 40 (1977),1935. .

Safety Profile

Confirmed human carcinogen producing leukemia. Experimental carcinogenic and tumorigenic data. Poison by ingestion, intraperitoneal, intravenous, and possibly other routes. Mutation data reported. Human systemic effects by ingestion: nausea or vomiting, damage to kidney tubules and glomeruli, and hematuria (blood in the urine). When heated to decomposition it emits very toxic fumes of Cl⁻ and NO_x. See also N-NITROSO COMPOUNDS.Safety information of Semustine (CAS NO.13909-09-6):
Hazard Codes Toxic T
Risk Statements
45 May cause cancer
46 May cause heritable genetic damage
23/24/25 Toxic by inhalation, in contact with skin and if swallowed
36/37/38 Irritating to eyes, respiratory system and skin
Safety Statements
53 Avoid exposure - obtain special instruction before use
22 Do not breathe dust
26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
36/37/39 Wear suitable protective clothing, gloves and eye/face protection
45 In case of accident or if you feel unwell, seek medical advice immediately (show label where possible)
RIDADR 3249
WGK Germany 3
RTECS YS5000000
HazardClass 6.1(a)
PackingGroup II

Specification

Organic amides react with azo and diazo compounds to generate toxic gases. Flammable gases are formed by the reaction of organic amides/imides with strong reducing agents. Amides are very weak bases (weaker than water). Imides are less basic yet and in fact react with strong bases to form salts. That is, they can react as acids. Mixing amides with dehydrating agents such as P₂O₅ or SOCl₂ generates the corresponding nitrile. The combustion of these compounds generates mixed oxides of nitrogen (NO_x).