Detail of "139106-80-2"

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Xenopus laevis c-myc I and II genes: molecular structure and developmental expression

Xenopus laevis c-myc I and II genes: molecular structure and developmental expression. Principaud, Etienne; Spohr, Georges (Dep. Biol. Cell., Univ. 139107-24-7 and 139107-25-8 are also occured in this study. Geneve, Geneva 1211, Switz.). Nucleic Acids Res., 19(11), 3081-8 (English) 1991. 139106-80-2 is just another one chemical used in this study. CODEN: NARHAD. ISSN: 0305-1048. DOCUMENT TYPE: Journal CA Section: 3 (Biochemical Genetics) Section cross-reference(s): 6, 12 The structure of the two Xenopus laevis c-myc I and c-myc II genes has been investigated by isolating and sequencing genomic and cDNA clones. In oocytes, c-myc I mRNAs represent 80-90% of the overall amt. of c-myc transcripts. The c-myc I expression is controlled primarily by two differentially regulated tandem promoters P1 and P2 which are sepd. by 50 bases. During oogenesis, maternal c-myc I mRNAs, are transcribed from both promoters whereas zygotic transcripts seem to initiate only from the P2 promoter. Sequence comparison between the promoter regions of c-myc I and II genes reveals the insertion in the c-myc I promoter region, between positions -831 and -389 relative to the P1 start site of a repetitive element. Comparison of X. laevis and mammalian c-myc promoter sequences reveals furthermore the conservation of cis-regulatory elements, including a motif known to be a neg. regulator of the human c-myc transcription, a purine rich region, a binding site for the E2-F transcription factor and three SP1 binding sites. Finally, the authors report characterization of a new c-myc I mRNA which differ at the 5' end. Transcripts are possibly initiated at a putative alternative promoter located further upstream in the genome, and undergo alternative splicing. ..