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| CAS No.: | 1402-68-2 |
|---|---|
| Name: | Aflatoxin |
| Molecular Structure: | |
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| Formula: | C17H14O6.C17H14O7.C17H12O6.C17H12O7 |
| Molecular Weight: | 1285.13 |
| Synonyms: | Aflatoxin;Flavatoxins; Toxins, afla |
| Density: | 1.59g/cm3 |
| Melting Point: | 268-269oC |
| Boiling Point: | 612.1°Cat760mmHg |
| Flash Point: | 274.2°C |
| Safety: | Confirmed human carcinogen with experimental tumorigenic data. Human poison by ingestion. An experimental teratogen. Other experimental reproductive effects. Mutation data reported. See also various aflatoxins. |
| PSA: | 84.20000 |
| LogP: | 1.86050 |
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Chemistry
Molecular Structure of Aflatoxin (CAS NO.1402-68-2):
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Empirical Formula: C17H12O7
Molecular Weight: 328.273
Index of Refraction: 1.68
Surface Tension: 70 dyne/cm
Density: 1.59 g/cm3
Flash Point: 274.2 °C
Enthalpy of Vaporization: 90.87 kJ/mol
Boiling Point: 612.1 °C at 760 mmHg
Vapour Pressure: 6.4E-15 mmHg at 25°C
Synonyms of Aflatoxin (CAS NO.1402-68-2): 1H,12H-furo[3',2':4,5]furo[2,3-h]pyrano[3,4-c][1]benzopyran-1,12-dione, 3,4,7a,10a-tetrahydro-5-methoxy- ; 3,4,7aa,10aa-Tetrahydro-5-methoxy-1H,12H-furo[3',2':4,5]furo[2,3-h]pyrano[3,4-c][1]benzopyran-1,12-dione ; 5-methoxy-3,4,7a,10a-tetrahydro-1H,12H-furo[3',2':4,5]furo[2,3-h]pyrano[3,4-c]chromene-1,12-dione ; (7AR,cis)3,4,7a,10a-tetrahydro-5-methoxy-1H,12H-furo(3',2':4,5)furo(2,3-h)pyrano(3,4-c)chromene-1,12-dione ; 1H,12H-Furo(3',2':4,5)furo(2,3-h)pyrano(3,4-c)(1)benzopyran-1,12-dione, 3,4,7a,10a-tetrahydro-5-methoxy-
Classification Code: Human Data ; Mutation data ; Reproductive Effect ; Tumor data
Production
Aflatoxin (CAS.NO.1402-68-2) are naturally occurring mycotoxins that are produced by many species of Aspergillus, a fungus, most notably Aspergillus flavus and Aspergillus parasiticus. Aflatoxins are toxic and among the most carcinogenic substances known.After entering the body, aflatoxins are metabolized by the liver to a reactive intermediate, aflatoxin M1, an epoxide.
Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| human | LDLo | oral | 229ug/kg/8W (0.229mg/kg) | BEHAVIORAL: ANOREXIA (HUMAN GASTROINTESTINAL: ULCERATION OR BLEEDING FROM SMALL INTESTINE LIVER: "JAUNDICE, OTHER OR UNCLASSIFIED" | Lancet. Vol. 1, Pg. 1061, 1975. |
| monkey | LD50 | intramuscular | 2020mg/kg (2020mg/kg) | LIVER: "HEPATITIS (HEPATOCELLULAR NECROSIS), ZONAL" | Food and Cosmetics Toxicology. Vol. 14, Pg. 227, 1976. |
| monkey | LD50 | oral | 1750ug/kg (1.75mg/kg) | LIVER: "HEPATITIS (HEPATOCELLULAR NECROSIS), ZONAL" | Food and Cosmetics Toxicology. Vol. 14, Pg. 227, 1976. |
| quail | LDLo | oral | 4mg/kg (4mg/kg) | British Poultry Science. Vol. 21, Pg. 29, 1980. |
Consensus Reports
NTP 10th Report on Carcinogens. IARC Cancer Review: Group 1 IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 7 (1987),p. 83.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Human Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 7 (1987),p. 83.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 7 (1987),p. 83.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210)
Safety Profile
Confirmed human carcinogen with experimental tumorigenic data. Human poison by ingestion. An experimental teratogen. Other experimental reproductive effects. Mutation data reported. See also various aflatoxins.
Chronic, subclinical exposure does not cause dramatic symptoms of acute aflatoxin poisoning. However, children are particularly affected by aflatoxin exposure which led to growth retardation and delayed development. Long-term exposure has also led to the development of liver cancer in high-riskAlloclamide.
Specification
Aflatoxin (CAS NO.1402-68-2) is a highly toxic chemicals, flammable, while burning it would produce stimulating smoke, so it needed to be stored in low temperature, ventilation, drying and oxidability environmental condition, separated with food ingredients , water, carbon dioxide , dry powder, sand, water mist fire extinguishing can be used if urgency.