Detail of "140212-86-8"

CAS Number:
140212-86-8
Name:
Azacycloeicosa-3,5,7,11,13,15,17-heptaen-2-one,20-(2-hexenyl)-9,10-dihydroxy-7,15-dimethyl- (9CI)
Molecular Structure:
Formula:
C27H37 N O3
Molecular Weight:
423.5876
Synonyms:
AntibioticBE 14106; BE 14106; GT 32A
Density:
0.99 g/cm³
Boiling Point:
640.5 °C at 760 mmHg
Flash Point:
341.2 °C

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Antitumor substance BE-14106 and its manufacture with a novel Streptomyces: Antitumor substance BE-14106 and its manufacture with a novel Streptomyces. Ojiri, Katsuhisa; Nakajima, Shigeru; Kondo, Hisao; Suzuki, Hajime; Okura, Akira; Suda, Hiroyuki; Okanishi, Masanori (Banyu Pharmaceutical Co., Ltd., Japan). Jpn. Kokai Tokkyo Koho JP 04001179 A2 6 Jan 1992 Heisei, 7 pp. (Japan). CODEN: JKXXAF. CLASS: ICM: C07D225-02. ICS: A61K031-395; C12N001-20; C12P017-10. ICI: C12N001-20, C12R001-465; C12P017-10, C12R001-465. APPLICATION: JP 90-101217 17 Apr 1990. DOCUMENT TYPE: Patent CA Section: 16 (Fermentation and Bioindustrial Chemistry) Section cross-reference(s): 1, 10 Antitumor substance BE-14106 (I) is manufd. by cultivation of I-producing microorganisms or their mutants. Streptomyces A14106 was shake-cultured in a medium contg. glucose, dextrin, corn gluten meal, fish meal, yeast ext., salts, etc. 140212-86-8 is the cas registry number of certain chemical which is used as reagents here., at 28° and pH 6.7 for 72 h, shake-cultured in the same medium at 28° for 144 h, the broth (~6 L) filtered, the cells washed with H2O, extd. with MeOH, and the MeOH ext. subjected to silica gel chromatog. to manuf. 186 mg I. I inhibited growth of mouse leukemia P388 cells with IC50 of 1.65 mM. The microbial properties of the bacteria are also described. .