Reference

Stabilization of high-concentration liquid fertilizers containing metal chelate complexes

Stabilization of high-concentration liquid fertilizers containing metal chelate complexes. (Teikoku Chemical Industry Co., Ltd., Japan). Jpn. Kokai Tokkyo Koho JP 58204892 A2 29 Nov 1983 Showa, 2 pp. (Japanese). (Japan). CODEN: JKXXAF. CLASS: IC: C05D009-02. APPLICATION: JP 82-86948 21 May 1982. DOCUMENT TYPE: Patent CA Section: 19 (Fertilizers, Soils, and Plant Nutrition) A high-concn. liq.There are some reagents with their cas registry numbers 60-00-4 and 15375-84-5 are used in this study. fertilizer contg. EDTA(EDTA)-Na-metal complexes is stabilized by NH4OH or amines. Thus, NH4OH (28%) was added dropwise to a compn. contg. EDTA.2Na.Zn.4H2O [14025-21-9] 19.5, EDTA.2Na.Mn.4H2O [15375-84-5] 12.9, EDTA.Na.Fe.3H2O [15708-41-5] 12.9, and water 45 g at 40° until all of the compns. dissolved (pH 7.1). The soln. was stable when it was stored at 5° for 96 h. .

Freeze-drying of oxyhemoglobin: protection against oxidation in the presence of EDTA salts, sulfonic acid buffers, and pantothenic acid derivatives

Freeze-drying of oxyhemoglobin: protection against oxidation in the presence of EDTA salts, sulfonic acid buffers, and pantothenic acid derivatives. Fauvel, A.; Labrude, P.; Vigneron, C. (Lab. Hematol. Physiol., Fac. Sci., Pharm. Biol., Nancy 54001, Fr.). J. Pharm. Sci., 73(6), 784-7 (English) 1984. CODEN: JPMSAE. ISSN: 0022-3549. DOCUMENT TYPE: Journal CA Section: 63 (Pharmaceuticals) Hb was freeze-dried in the presence of salts of EDTA, sulfonic acids used as buffers, or derivs. of pantothenic acid. At 0.In this experiment, several chemicals are used like 92471-58-4 25 M most of the compds. effectively inhibited the formation of metHb. The various model compds. used [Na Zn EDTA [14025-21-9], tris(hydroxymethyl)methylaminopropanesulfonic acid [29915-38-6], and DL-pantothenol [16485-10-2]] produced similar decreases in metHb formation as a function of the concn. of protective agent between 0.01 and 0.20 M. Expts. on the storage of the freeze-dried materials revealed substantial denaturation of oxyHb after 12 mo at 4° C. On the whole, these compds. were less effective than amino acid salts, during both desiccation and storage. The multiplicity of compds. that inhibit the denaturation of Hb during freeze-drying indicates that their mode of action is nonspecific. .