Detail of "1403-71-0"

CAS Number:
1403-71-0
Name:
Hamycin
Molecular Weight:
0
Synonyms:
Primamycin
Safety:
Poison by intravenous and intraperitoneal routes. Moderately toxic by ingestion. Details

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Hypocholesterolemic and prostate gland reduction activity of hamycin: Hypocholesterolemic and prostate gland reduction activity of hamycin. Naik, S. R. (Pharmacol. Toxicol. Lab., Hindustan Antibiotics Res. Cent., Pune 411 018, India). Hind. Antibiot. Bull., 26(1-2), 1-8 (English) 1984. CODEN: HINAAU. ISSN: 0018-1935. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Hamycin [1403-71-0], like other polyene macrolides, showed significant hypocholesterolemic activity, reduced prostate wt. and size, and decreased serum testosterone [58-22-0] levels in rats. Prostate redn. with hamycin may not be strictly related to its hypocholesterolemic activity. The possibility of direct or indirect involvement of hypophyseal-gonadal axis in the effect of hamycin is suggested.

Effect of hamycin on prostatatic secretion and serum testosterone levels in the rat: Effect of hamycin on prostatatic secretion and serum testosterone levels in the rat. Naik, S. R. (Res. Cent., Hindustan Antibiot. Ltd., Poona City 411 018, India). Hind. Antibiot. Bull., 25(3-4), 125-30 (English) 1983. CODEN: HINAAU. ISSN: 0018-1935. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Section cross-reference(s): 2 Hamycin (I) [1403-71-0] (25 mg/kg, orally for 4 wk) treatment in rabbits decreased prostatic wt. and fluid secretion. The decrease in prostate secretion was completely reversed by administration of testosterone propionate [57-85-2]. Addnl., serum testosterone [58-22-0] levels of chronically I-treated were markedly lower than controls. Decreased cholesterol [57-88-5] levels were also obsd. after 4 wk of I treatment.