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Basic Information

Molecular Structure:
CAS No.:	1405-41-0
Name:	Gentamycin sulfate

Formula:	C₂₁H₄₃N₅O₇^.H₂SO₄
Molecular Weight:	575.67
Synonyms:	Gentalline;Pred-G S.O.P.;Gentocin (Veterinary);Gentocin (sulfate);Garamycin (TN);Gentacin;Geramycin;Gentocin;Prestwick_240;Septopal;Gentamicin,sulfate (salt);Gentamicin C complex sulfate;Gentamicins;Topagen (Veterinary);Gentamycin sulphat;Gentamycin Solution;Gentamicin sulphate;Alcomicin;Garasol (Veterinary);
EINECS:	215-778-9
Density:	==
Melting Point:	218-237 °C
Boiling Point:	797.6 °C at 760 mmHg
Flash Point:	436.2 °C
Solubility:	water: 50 mg/mL
Appearance:	White crystalline powder
Hazard Symbols:	Xn
Risk Codes:	42/43
Safety:	23-36/37-45-22-24/25
PSA:	719.38000
LogP:	-1.26180

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Chemistry

Formula of Gentamycin sulfate (CAS NO.1405-41-0): C₂₁H₄₃N₅O₇.H₂SO₄Molecular Weight: 575.67
Flash Point: 436.2 °C
Enthalpy of Vaporization: 132.12 kJ/mol
Boiling Point: 797.6 °C at 760 mmHg
Melting point: 218-237 °C(lit.)
Structure of Gentamycin sulfate (CAS NO.1405-41-0):

IUPAC Name: 2-[4,6-Diamino-3-[3-amino-6-[1-(methylamino)ethyl]oxan-2-yl]oxy-2-hydroxycyclohexyl]oxy-5-methyl-4-(methylamino)oxane-3,5-diol; sulfuricacid

Uses

Gentamycin sulfate (CAS NO.1405-41-0) can be used as biochemical reagent, for example in some medicine use, as the antibacterial medicine. And it can be the medicine for the treatment of sepsis, urinary tract infection, staphylococcus infection, endocarditis and other diseases.

Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
guinea pig	LD50	subcutaneous	600mg/kg (600mg/kg)		Chemotherapy Vol. 16, Pg. 105, 1968.
man	TDLo	intravenous	21mg/kg/6D-I (21mg/kg)		Drug Intelligence and Clinical Pharmacy. Vol. 18, Pg. 596, 1984.
mouse	LD50	intracrebral	17300ug/kg (17.3mg/kg)	PERIPHERAL NERVE AND SENSATION: SENSORY CHANGE INVOLVING PERIPHERAL NERVE BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE	Chemotherapy Vol. 15, Pg. 483, 1967.
mouse	LD50	intramuscular	250mg/kg (250mg/kg)	BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION	Jitchuken Zenrinsho Kenkyuho. Central Institute for Experimental Animals, Research Reports. Vol. 8, Pg. 219, 1982.
mouse	LD50	intraperitoneal	245mg/kg (245mg/kg)	BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Jitchuken Zenrinsho Kenkyuho. Central Institute for Experimental Animals, Research Reports. Vol. 8, Pg. 219, 1982.
mouse	LD50	intravenous	47mg/kg (47mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: DYSPNEA	Japanese Journal of Antibiotics. Vol. 39, Pg. 3164, 1986.
mouse	LD50	oral	> 11269mg/kg (11269mg/kg)		Drugs in Japan Vol. 6, Pg. 268, 1982.
mouse	LD50	subcutaneous	478mg/kg (478mg/kg)		Journal of Antibiotics. Vol. 23, Pg. 551, 1970.
rat	LD50	intramuscular	384mg/kg (384mg/kg)		Toxicology and Applied Pharmacology. Vol. 18, Pg. 185, 1971.
rat	LD50	intraperitoneal	630mg/kg (630mg/kg)	BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES	Japanese Journal of Antibiotics. Vol. 26, Pg. 221, 1973.
rat	LD50	intravenous	96mg/kg (96mg/kg)	BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION	Jitchuken Zenrinsho Kenkyuho. Central Institute for Experimental Animals, Research Reports. Vol. 8, Pg. 219, 1982.
rat	LD50	oral	> 5gm/kg (5000mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) SKIN AND APPENDAGES (SKIN): HAIR: OTHER	Jitchuken Zenrinsho Kenkyuho. Central Institute for Experimental Animals, Research Reports. Vol. 8, Pg. 219, 1982.
rat	LD50	subcutaneous	873mg(base)/k (873mg/kg)		Antibiotiki i Khimioterapiya. Antibiotics and Chemotherapy. Vol. 35(9), Pg. 26, 1990.
women	TDLo	intravenous	45mg/kg/1W-I (45mg/kg)		Drug Intelligence and Clinical Pharmacy. Vol. 18, Pg. 596, 1984.

Safety Profile

GENTAMYCIN sulfate's human systemic effects: level changes for metals other than Na/K/Fe/Ca/P/Cl. An experimental teratogen. Other experimental reproductive effects. Mutation data reported. When heated to decomposition it emits very toxic fumes of SO_x.
Hazard Symbols of Gentamycin sulfate (CAS NO.1405-41-0): Harmful Xn
Risk Codes: R42/43
R42/43:May cause sensitization by inhalation and skin contact.
Safety Description: S23;S36/37;S45
S23:Do not breathe vapour.
S36/37:Wear suitable protective clothing and gloves.
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)

Specification

Gentamycin sulfate , its cas register number is 1405-41-0. It also can be called Garamycin ; and 2-[4,6-Diamino-3-[3-amino-6-(1-methylaminoethyl)oxan-2-yl]oxy-2-hydroxy-cyclohexoxy]-5-methyl-4-methylamino-oxane-3,5-diol sulphate .