Reference

Identification of aminoglycoside antibiotics by NMR spectroscopy

Identification of aminoglycoside antibiotics by NMR spectroscopy. Kartashov, V. S.; Chernyshev, A. I.; Arzamastsev, A. P.; Esipov. S. E. (I MMI, Moscow, USSR). Khim.-Farm. Zh., 17(9), 1139-45 (Russian) 1983. CODEN: KHFZAN. ISSN: 0023-1134. 1263-89-4 and 1405-10-3 are also in the experiment. DOCUMENT TYPE: Journal CA Section: 63 (Pharmaceuticals) Section cross-reference(s): 26, 64 Aminoglycoside antibiotics, streptomycin sulfate [3810-74-0], dihydrostreptomycin sulfate [5490-27-7] neomycin sulfate [1405-10-3], monomycin sulfate [1263-89-4], kanamycin sulfate [25389-94-0], tobramycin sulfate [49842-07-1], gentamycin sulfate [1405-41-0], and sisomycin sulfate [53179-09-2] were characterized by NMR. The spectra were run as 5% solns. in D2O on a pulsed 90 mHz spectrometer at 40°. The chem. shifts were measured by using Na 2,2-dimethyl-2-silapentane-5-sulfonate as the internal std. Signals corresponding to various protons in the antibiotics were identified by chem. shift and spin-spin coupling measurements. Structural proof for these antibiotics is given based on NMR measurements. .

Compatibility of cephacetrile sodium injection

Compatibility of cephacetrile sodium injection. Koshiro, Akira; Fujita, Toshio (Dep. Pharm., Yamaguchi Univ. Hosp., Ube 755, Japan). Byoin Yakugaku, 9(5), 398-406 (Japanese) 1983. CODEN: BYYADW. DOCUMENT TYPE: Journal CA Section: 63 (Pharmaceuticals) The compatibility of cephacetrile sodium (I) [23239-41-0] with 71 additives was examd. in 5% glucose soln. contg. vitamin B complexes (thiamine hydrochloride, FAD and pyridoxal phosphate). Each ampul or vial was dissolved in 50 mL of glucose soln., where a higher concn. was 10-fold as high as that of the usual prepn. Kanamycin sulfate [25389-94-0], Vistamycin [25546-65-0], Futraful [17902-23-7], Diamox [59-66-5], Neophyllin [479-18-5], Meylon [144-55-8], Stronger Neo Minophagen C [88863-96-1], Proteamin 12X, 5-FU [51-21-8] and urokinase [9039-53-6] accelerated the degrdn. of cephacetrile. 1405-41-0 and 943-17-9 are also in the experiment. The compatibility of these additives was reexamd. under conditions in which each injection was mixed in 500 mL glucose soln., and all the admixts. except for Neophyllin showed the residual amts. above 90% after 6 h and were compatible. White turbidity was found in the admixts. of FOY [56974-61-9], Novamin and Wintermin which may be due to the formation of the salts of the components with cephacetrile with low soly. .