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| CAS No.: | 1406-11-7 |
|---|---|
| Name: | Polymixin-B-Sulfate |
| Molecular Structure: | |
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| Formula: | C48H82N16O14 |
| Molecular Weight: | 1107.26348 |
| Synonyms: | Polymixin |
| Density: | 1.36g/cm3 |
| Boiling Point: | °Cat760mmHg |
| Flash Point: | °C |
| Safety: | Poison by intraperitoneal, subcutaneous, and intravenous routes. An additive permitted in food for human consumption. |
| PSA: | 545.79000 |
| LogP: | 0.64470 |
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Chemistry
Product Name: Polymyxin (CAS NO.1406-11-7)
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Molecular Formula: C48H82N16O14
Molecular Weight: 1107.2635g/mol
Mol File: 1406-11-7.mol
Density: 1.36 g/cm3
Surface Tension: 76.4 dyne/cm
XLogP3-AA: -8
H-Bond Donor: 19
H-Bond Acceptor: 19
Structure Descriptors of Polymyxin (CAS NO.1406-11-7):
InChI : InChI=1/C48H82N16O14/c1-24(2)22-34-44(73)57-28(10-16-49)38(67)56-31(13-19-52)42(71)63-36(25(3)65)46(75)54-21-15-33(41(70)55-29(11-17-50)40(69)61-35(45(74)60-34)23-27-8-6-5-7-9-27)58-39(68)30(12-18-51)59-47(76)37(26(4)66)64-43(72)32(14-20-53)62-48(77)78/h5-9,24-26,28-37,62,65-66H,10-23,49-53H2,1-4H3,(H,54,75)(H,55,70)(H,56,67)(H,57,73)(H,58,68)(H,59,76)(H,60,74)(H,61,69)(H,63,71)(H,64,72)(H,77,78)/t25-,26-,28+,29+,30+,31+,32+,33+,34+,35-,36+,37+/m1/s1
Smiles: CC(C)C[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CCN)NC(=O)[C@H](CCNC(=O)[C@@H](NC(=O)[C@H](CCN)NC(=O)[C@H](CCN)NC1=O)[C@@H](C)O)NC(=O)[C@H](CCN)NC(=O)[C@@H](NC(=O)[C@H](CCN)NC(O)=O)[C@@H](C)O
Uses
Polymyxin antibiotics are considered relatively neurotoxic and nephrotoxic[6] and, though effective, are therefore used only if less toxic antibiotics are ineffective or are contraindicated. Typical use cases are infections with strains of Pseudomonas aeruginosa or Enterobacteriaceae species that are highly resistant to other types of antibiotics such as cephalosporins.
Polymyxins (CAS NO.1406-11-7) are used to neutralize or absorb LPS contaminating samples that are intended for use in e.g. immunological experiments. Minimization of LPS contamination can be important because LPS can evoke strong reactions from immune cells and therefore distort experimental results.
Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| dog | LDLo | intravenous | 25mg/kg (25mg/kg) | PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES | Annals of the New York Academy of Sciences. Vol. 51, Pg. 935, 1949. |
| mouse | LD50 | intraperitoneal | 77mg/kg (77mg/kg) | Annals of the New York Academy of Sciences. Vol. 51, Pg. 879, 1949. | |
| mouse | LD50 | intravenous | 18mg/kg (18mg/kg) | Annals of the New York Academy of Sciences. Vol. 51, Pg. 879, 1949. | |
| mouse | LD50 | subcutaneous | 250mg/kg (250mg/kg) | PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE) BEHAVIORAL: ATAXIA LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES | Annals of the New York Academy of Sciences. Vol. 51, Pg. 935, 1949. |
Safety Profile
Poison by intraperitoneal, subcutaneous, and intravenous routes. An additive permitted in food for human consumption.
Specification
Polymyxin ,its CAS NO. is 1406-11-7,the synonyms is B-71 ; Caswell No. 678 ; EPA Pesticide Chemical Code 006305 ; Polymyxinum .