Reference

Preparation and spectroscopic characterization of the monofluorohydro-closo-borates [B6H5F]2- and [B12H11F]2-

Preparation and spectroscopic characterization of the monofluorohydro-closo-borates [B6H5F]2- and [B12H11F]2-. Thomsen, H.; Haeckel, O.; Krause, U.; Preetz, W. (Inst. Anorg. Chem. Christian-Albrechts-Univ., Kiel, Germany). Zeitschrift fuer Anorganische und Allgemeine Chemie, 622(12), 2061-2064 (German) 1996 Barth. CODEN: ZAACAB. ISSN: 0044-2313. DOCUMENT TYPE: Journal CA Section: 78 (Inorganic Chemicals and Reactions) Section cross-reference(s): 73 By treatment of [B6H6]2- with 1-(chloromethyl)-4-fluoro-1,4-diazabicyclo[2.2.2]octane bis(tetrafluoroborate) in MeCN, monofluorohydro-closo-hexaborate [B6H5F]2- (1) is formed in good yields. [B12H12]2- reacts with anhyd. 140681-55-6 and 186365-08-2 are cas registry numbers of chemicals which are used as reagents here. HF yielding the monofluorododecaborate [B12H11F]2- (2). These compds. are sepd. by ion exchange chromatog. on diethylaminoethyl(DEAE) cellulose from byproducts. The 11B NMR spectra exhibit the characteristic patterns (1:4:1) of a monosubstituted B6 octahedron and (1:5:5:1) of a monosubstituted B12 icosahedron with strong downfield shifts of the ipso-B nuclei at +9.3 ppm (1) and at +9.0 ppm (2). The 19F NMR spectra reveal quartets at -212 ppm (1) and -209 ppm (2) proving a B-F bonding. In the IR spectra, for (1) in the Raman spectrum too, cage vibrations depending on the F substituent at 1195 (1) and at 1182/1154 cm-1 (2) are obsd. The Raman spectra show the B6F stretching mode at 534 cm-1 and the B12F stretching vibration at 445 cm-1. .

Synthesis of carbocyclic 2',3'-dideoxy-2'-fluoro-3'-C-hydroxymethyl nucleoside analogs as potential inhibitors of HIV and HSV

Synthesis of carbocyclic 2',3'-dideoxy-2'-fluoro-3'-C-hydroxymethyl nucleoside analogs as potential inhibitors of HIV and HSV. Wachtmeister, Johanna; Classon, Bjoern; Samuelsson, Bertil; Kvarnstroem, Ingemar (Arrhenius Lab., Stockholm Univ., Stockholm S-10691, Swed.). Tetrahedron, 53(5), 1861-1872 (English) 1997 Elsevier. CODEN: TETRAB. ISSN: 0040-4020. DOCUMENT TYPE: Journal CA Section: 33 (Carbohydrates) Section cross-reference(s): 1 The synthesis of four isomerically pure fluoro-carbocyclic adenosine and guanosine analogs is described.Several substances with their cas registry numbers 187878-34-8 and 140681-55-6 may be metioned in this study. The 3S,4S-bis(t-butyldiphenylsilyloxymethyl)-2-fluoropentan-1-ol derivs. I synthesized from enantiomerically pure 3S,4S-bis(t-butyldiphenylsilyloxymethyl)-cyclopentanone, were coupled with chloropurines using the Mitsunobu procedure to give II (X = H, Y = F; X = F, Y = H) or converted to their corresponding 1-amino derivs., from which the fluoro-carbocyclic guanosine analogs were prepd. The title compds. were evaluated as potential anti-viral agents but were found to be inactive. .