Detail of "140853-10-7"

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Studies on the construction of abutasterone-type and 24-epi-abutasterone-type side chains employing asymmetric dihydroxylation of (E)-20(22),24-cholestadiene

Several substances are used for example 140853-10-7 which is its cas registry number.There are some reagents like 140853-10-7 is used in this study. Studies on the construction of abutasterone-type and 24-epi-abutasterone-type side chains employing asymmetric dihydroxylation of (E)-20(22),24-cholestadiene. Tsubuki, Masayoshi; Iwabuchi, Kazuo; Honda, Toshio (Faculty of Pharmaceutical Sciences, Hoshi University 2-4-41 Ebara, Shinagawa-ku, Tokyo 142-8501, Japan). Tetrahedron: Asymmetry, 16(23), 3913-3918 (English) 2005 Elsevier B.V. CODEN: TASYE3. ISSN: 0957-4166. DOCUMENT TYPE: Journal CA Section: 32 (Steroids) The synthesis of abutasterone-type side chain, (20R,22R,24S)-20,22,24,25-tetrahydroxy-6b-methoxy-3a,5-cyclo-5a-c holestane (I), and 24-epi-abutasterone-type side chain, (20R,22R,24R)-20,22,24,25-tetrahydroxy-6b-methoxy-3a,5-cyclo-5a-c holestane (II), by means of Sharpless asym. dihydroxylation of (E)-20(22),24-cholestadiene (III) is described. Construction of abutasterone-type side chain I was carried out by selective mono-dihydroxylation of diene III with (DHQ)2AQN, followed by dihydroxylation of the corresponding (24S)-hydroxy-20(22)-cholestene with (DHQD)2AQN. In contrast, bis-dihydroxylation of III with either (DHQD)2PHAL or (DHQD)2AQN preferentially occurs to produce 24-epi-abutasterone-type side chain II. ..

Studies on the construction of abutasterone-type and 24-epi-abutasterone-type side chains employing asymmetric dihydroxylation of (E)-20(22),24-cholestadiene

Several substances are used for example 140853-10-7 which is its cas registry number.There are some reagents like 140853-10-7 is used in this study. Studies on the construction of abutasterone-type and 24-epi-abutasterone-type side chains employing asymmetric dihydroxylation of (E)-20(22),24-cholestadiene. Tsubuki, Masayoshi; Iwabuchi, Kazuo; Honda, Toshio (Faculty of Pharmaceutical Sciences, Hoshi University 2-4-41 Ebara, Shinagawa-ku, Tokyo 142-8501, Japan). Tetrahedron: Asymmetry, 16(23), 3913-3918 (English) 2005 Elsevier B.V. CODEN: TASYE3. ISSN: 0957-4166. DOCUMENT TYPE: Journal CA Section: 32 (Steroids) The synthesis of abutasterone-type side chain, (20R,22R,24S)-20,22,24,25-tetrahydroxy-6b-methoxy-3a,5-cyclo-5a-c holestane (I), and 24-epi-abutasterone-type side chain, (20R,22R,24R)-20,22,24,25-tetrahydroxy-6b-methoxy-3a,5-cyclo-5a-c holestane (II), by means of Sharpless asym. dihydroxylation of (E)-20(22),24-cholestadiene (III) is described. Construction of abutasterone-type side chain I was carried out by selective mono-dihydroxylation of diene III with (DHQ)2AQN, followed by dihydroxylation of the corresponding (24S)-hydroxy-20(22)-cholestene with (DHQD)2AQN. In contrast, bis-dihydroxylation of III with either (DHQD)2PHAL or (DHQD)2AQN preferentially occurs to produce 24-epi-abutasterone-type side chain II. ..