Detail of "14144-06-0"

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Effects of synthetic glycosides on steroid balance in Macaca fascicularis

Effects of synthetic glycosides on steroid balance in Macaca fascicularis. Malinow, M. Rene; Elliott, William H.; McLaughlin, Phyllis; Upson, Barbara (Lab. Cardiovasc. Dis., Oregon Reg. Prim. Res. Cent., Beaverton, OR 97006, USA). J. Lipid Res., 28(1), 1-9 (English) 1987. CODEN: JLPRAW. ISSN: 0022-2275. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) The effects of the b-anomer of diosgenin glucoside (DG)(I) [14144-06-0] on cholesterol homeostasis were tested in monkeys. Cynomolgus macaques (M. fascicularis) were fed, during 2 3-wk periods, a semipurified diet with 0.1% cholesterol and a similar ration contg. 1% DG, resp. A Chow diet was given for 5 wk between the exptl. periods. Cholesterol and bile acid balance were analyzed during the last week of each semipurified diet. Diosgenin glucoside reduced cholesterolemia from 292 mg/dL to 172 mg/dL, decreased intestinal absorption of exogenous cholesterol from 62.4% to 26.0%, and increased secretion of endogenous cholesterol from -0.8 to 93.5 mg/day. The fetal excretion of neutral steroids rose from 40.7 to 157. 83-44-3 and 14144-06-0 which are cas registry numbers of substances are two of reagents here.3 mg/day; that of bile acids changed, nonsignificantly, from 23.1 to 16.0 mg/day. The cholesterol balance was -44 mg/day in the control period and 88 mg/day in the DG-fed animals. No toxic signs were obsd. Thus, when long-term studies demonstrate that the glucoside is well tolerated, DG and other synthetic glycosides with similar activities may be of use in the management of hypercholesterolemia and atherosclerosis. .

Biotransformation of polyphyllins by Curvularia lunata fermentation

All Rights Reserved. Biotransformation of polyphyllins by Curvularia lunata fermentation. Feng, Bing; Ma, Baiping; Kang, Liping; Xiong, Chengqi; Wang, Shengqi (Institute of Radiation Medicine, Academy of Military Medical Sciences, Beijing 100850, Peop. Rep. China). Zhongcaoyao, 36(7), 978-982 (Chinese) 2005 Zhongcaoyao Zazhi Bianjibu. CODEN: CTYAD8. ISSN: 0253-2670. DOCUMENT TYPE: Journal CA Section: 10 (Microbial, Algal, and Fungal Biochemistry) The aim of this study was to find microorganisms which hydrolyzed sugar residues of steroidal saponins at C-3 position and to obtain their glucosyl derivs. The enzymes secreted by fermn. of C.In this article, certain chemicals are used. Some of their cas registry numbers are 14144-06-0 and 55916-51-3 lunata (3.4381) in the culture medium were employed to transform polyphyllin V and polyphyllin VI. The products were sepd. by chromatog. on C18 column, and their structures were elucidated on the basis of spectral analyses. Compds. I and II could be transformed by C. lunata (3.4381), and the main products were identified as diosgenin 3-O-b-D-glucopyranoside, named trillin, and pennogenin-3-O-b-D-glucopyranoside, resp. The terminal rhamnosyls of polyphyllin V and polyphyllin VI at C-3 position could be hydrolyzed selectively by C. lunata (3.4381) for the 1st time. .