Detail of "141776-91-2"

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CAS Number:
141776-91-2
Name:
Benzene,1-(bromomethyl)-3,5-difluoro-
Superlist Name:
3,5-Difluorobenzyl bromide
Molecular Structure:
Formula:
C₇H₅BrF₂
Molecular Weight:
207.0154
Synonyms:
1-Bromomethyl-3,5-difluorobenzene;
Density:
1.6 g/cm³
Boiling Point:
205.1 °C at 760 mmHg
Flash Point:
81.7 °C
Appearance:
Colorless to light yellow liquid
Hazard Symbols:
C
Risk Codes:
34-36
Safety:
26-36/37/39-45-27 Details
Transport Information:
UN 3265 8/PG 2

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Reference

Indole-3-carbonyl-spiro-piperidine derivatives as V1a receptor antagonists and their preparation, pharmaceutical compositions and use in the treatment of diseases: All Rights Reserved. Some chemicals with cas registry numbers like 920023-07-0 and 141776-91-2 are also used. Indole-3-carbonyl-spiro-piperidine derivatives as V1a receptor antagonists and their preparation, pharmaceutical compositions and use in the treatment of diseases. Bissantz, Caterina; Grundschober, Christophe; Ratni, Hasane; Rogers-Evans, Mark; Schnider, Patrick (F. Hoffmann-La Roche A.-G., Switz.). PCT Int. Appl. WO 2007006688 A1 18 Jan 2007, 292pp. DESIGNATED STATES: W: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC; RW: AT, BE, BF, BJ, CF, CG, CH, CI, CM, CY, DE, DK, ES, FI, FR, GA, GB, GR, IE, IS, IT, LU, MC, ML, MR, NE, NL, PT, SE, SN, TD, TG, TR. (English). (World Intellectual Property Organization). CODEN: PIXXD2. APPLICATION: WO 2006-EP63846 4 Jul 2006. PRIORITY: EP 2005-106443 14 Jul 2005; EP 2005-109364 7 Oct 2005. DOCUMENT TYPE: Patent CA Section: 27 (Heterocyclic Compounds (One Hetero Atom)) Section cross-reference(s): 1, 63 This invention relates to indol-3-yl-carbonyl-spiro-piperidine derivs. of formula I, which act as V1a receptor antagonists. The invention further relates to pharmaceutical compns. contg. such compds., their use in medicaments against dysmenorrhea, hypertension, chronic heart failure, inappropriate secretion of vasopressin, liver cirrhosis, nephrotic syndrome, obsessive compulsive disorder, anxious and depressive disorders, and methods of prepn. thereof. Compds. of formula I wherein A is (un)substituted spiro-indene-piperidine, (un)substituted spiro-indane-piperidine, (un)substituted spiro-indoline-piperidine, (un)substituted spiro-benzofuran-piperidine, etc.; R1 is H, (un)substituted C1-6 alkyl, (un)substituted aryl, (un)substituted 5- to 6-membered (hetero)aryl, and (un)substituted sulfonylaryl, etc.; R2 is H, halo, CN, NO2, (un)substituted C1-6 alkyl, etc.; R3 is H, halo, acyl, (un)substituted C1-6 alkyl, (un)substituted aryl, etc.; and their pharmaceutically acceptable salts thereof are claimed. Example compd. II was prepd. by benzylation of 2-methyl-1H-indole-carboxylic acid with 1-benzyl bromide; the resulting 1-benzyl-2-methyl-1H-indole-carboxylic acid underwent amidation with spiro[indene-1,4'-piperidine] to give compd. II. All the invention compds. were evaluated for their V1a receptor antagonistic activity. From the assay, it was detd. that compd. II exhibited an Ki value of 6.8 nM. .

Detail of "141776-91-2"

Benzene,1-(bromomethyl)-3,5-difluoro-

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CAS No.141776-91-2 3,5-Difluorobenzyl bromide

CAS No.141776-91-2 3,5-Difluorobenzyl bromide

CAS No.141776-91-2 3,5-Difluorobenzyl bromide

CAS No.141776-91-2 3,5-Difluorobenzyl bromide

CAS No.141776-91-2 3,5-Difluorobenzyl bromide

CAS No.141776-91-2 3,5-Difluorobenzyl bromide

CAS No.141776-91-2 3,5-Difluorobenzyl bromide

CAS No.141776-91-2 3,5-Difluorobenzyl bromide

CAS No.141776-91-2 3,5-Difluorobenzyl bromide

CAS No.141776-91-2 3,5-Difluorobenzyl bromide

CAS No.141776-91-2 3,5-Difluorobenzyl bromide

CAS No.141776-91-2 3,5-Difluorobenzyl bromide

CAS No.141776-91-2 3,5-Difluorobenzyl bromide

CAS No.141776-91-2 3,5-Difluorobenzyl bromide

CAS No.141776-91-2 3,5-Difluorobenzyl bromide

CAS No.141776-91-2 3,5-Difluorobenzyl bromide

CAS No.141776-91-2 3,5-Difluorobenzyl bromide

CAS No.141776-91-2 3,5-Difluorobenzyl bromide

CAS No.141776-91-2 3,5-Difluorobenzyl bromide

CAS No.141776-91-2 3,5-Difluorobenzyl bromide

CAS No.141776-91-2 3,5-Difluorobenzyl bromide

Reference