Detail of "142-83-6"

Reference

Odor detectability of aldehydes and alcohols originating from lipid oxidation

Odor detectability of aldehydes and alcohols originating from lipid oxidation. Eriksson, C. E.; Lundgren, B.; Vallentin, K. (Sect. Biochem., Swed. Inst. Food Preserv., Goteborg, Swed.). Chem. Senses Flavor, 2(1), 3-15 (English) 1976. CODEN: CSFLA4. DOCUMENT TYPE: Journal CA Section: 3 (Biochemical Interactions) Section cross-reference(s): 17 Odor detection thresholds were detd. for n-hexanol [111-27-3], n-hex-trans-2-en-1-ol [928-95-0], n-hex-2,4-dien-1-ol [111-28-4], n-hept-trans-2-en-1-ol [33467-76-4], n-oct-trans-2-en-1-ol [18409-17-1], and the corresponding aldehydes in water by adult subjects, and all alcs. had higher odor threshold values than did the corresponding aldehydes. For both the C-6 alcs. and the C-6 aldehydes, the threshold values increased with degree of unsatn.; for the 2-monounsatd. compds., the threshold decreased in the order C-6>C-7>C-8. The significance of the odor detectability of these alcs. and aldehydes is discussed in relation to food flavor.Except for chemicals metioned above, 142-83-6 and 6728-26-3 are also used. .

Toxicology and carcinogenesis studies of 2,4-hexadienal (89% trans,trans isomer, CAS No

Toxicology and carcinogenesis studies of 2,4-hexadienal (89% trans,trans isomer, CAS No. 142-83-6; 11% cis,trans isomer) in F344/N rats and B6C3F1 mice (gavage studies). (U.S. Department of Health and Human Services; National Toxicology Program, Research Triangle Park, NC 27709, USA). National Toxicology Program Technical Report Series, 509, i-ii, 1-290 (English) 2003. CODEN: NTPSE3. ISSN: 0888-8051. DOCUMENT TYPE: Report CA Section: 4 (Toxicology) 2,4-Hexadienal occurs naturally as an oxidn. product of fatty acids, esp. in heating and cooking of oils and fats. It is also used as a flavoring agent and as the starting material for making sorbic acid, a preservative. The authors deposited solns. of 2,4-hexadienal dissolved in corn oil through a tube directly into the forestomachs of male and female rats and mice daily, 5 times a week, for 2 yr. Rats received doses of 22.5, 45, or 90 mg 2,4-hexadienal per kg of body wt.; mice received doses of 30, 60, or 120 mg 2,4-hexadienal per kg of body wt. Control groups received corn oil with no 2,4-hexadienal added. At the end of the study, tissue samples from over 40 different organs were examd. for each animal. In all 4 study sets (male and female rats and mice), animals receiving 2,4-hexadienal had significantly greater occurrences of neoplasms of the forestomach. The forestomach in rodents is similar in tissue type to the esophagus in humans. These tumors included papillomas and malignant carcinomas. Normally such tumors of the forestomach are rare in rodents. Thus, 2,4-hexadienal caused neoplasms of the forestomach in male and female rats and mice.