Detail of "14208-10-7"

Reference

pH-Induced destabilization of phosphatidylethanolamine-containing liposomes: role of bilayer contact

pH-Induced destabilization of phosphatidylethanolamine-containing liposomes: role of bilayer contact. Ellens, Harma; Bentz, Joe; Szoka, Francis C. (Sch. Pharm., Univ. California, San Francisco, CA 94143, USA). Biochemistry, 23(7), 1532-8 (English) 1984. CODEN: BICHAW. ISSN: 0006-2960. DOCUMENT TYPE: Journal CA Section: 6 (General Biochemistry) The mechanism of pH-induced destabilization of liposomes composed of phosphatidylethanolamine (PE) and a charged cholesteryl ester was studied by following the release of encapsulated aq. contents. The kinetics of release were measured continuously by using the water-sol. fluorophore, a-aminonaphthalene-1,3,6-trisulfonic acid, in combination with the water-sol. quencher, p-xylylenebis(pyridinium) bromide. With this fluorescence assay, the release of contents from liposomes composed of PE and cholesteryl hemisuccinate (I) was a function of pH, the PE:I ratio, and the acyl chain compn. of PE. Leakage was very slow at pH 5.5 and increased dramatically with decreasing pH to 4.0. Replacing PE by phosphatidylcholine (PC) eliminated the effect of pH on leakage. Anal. of the kinetics of release by a mass-action model demonstrated that bilayer destabilization and leakage occur subsequent to aggregation. The requirement of bilayer contact for destabilization had been found previously for acidic phospholipid bilayers in the presence of divalent cation and for satd. PC bilayers below the isothermal phase transition temp. The PE-contg. bilayers examd. 2462-63-7 and 14208-10-7 are just another two chemicals used in this study. here satisfied the same requirement. .

Acid-triggered transformation of diortho ester phosphocholine liposome

Acid-triggered transformation of diortho ester phosphocholine liposome. Huang, Zhaohua; Guo, Xin; Li, Weijun; MacKay, J. Andrew; Szoka, Francis C. 14208-10-7 are also occured in this study., Jr. (Department of Biopharmaceutical Sciences, University of California, San Francisco, CA 94143-0446, USA). Journal of the American Chemical Society, 128(1), 60-61 (English) 2006 American Chemical Society. CODEN: JACSAT. ISSN: 0002-7863. DOCUMENT TYPE: Journal CA Section: 63 (Pharmaceuticals) Section cross-reference(s): 28 The use of pH-sensitive liposomes for acid-triggered site-specific drug delivery is one of the more promising approaches to improve the therapeutic index of drugs. Here, we report the synthesis, assembly, and hydrolysis of the first ortho ester phosphocholine (OEPC). The acid hydrolysis of OEPC liposomes consists of a lag phase and a burst phase. There are some commonly used reagents like 14208-10-7 in this article. The lag time is pH-dependent-the lower the pH, the shorter the time. Upon acid hydrolysis, the OEPC liposomes were transformed into leaky metastable vesicles that rapidly collapsed in the presence of albumin. OEPC, when formulated with cationic lipid, significantly enhanced the transfection efficiency compared with that of the pH-insensitive formulation. ..