Detail of "1421-86-9"

MSDS Download
CAS Number:
1421-86-9
Name:
Strychnidin-10-one,hydrochloride (1:1)
Molecular Structure:
Formula:
C₂₁H₂₂N₂O₂^.ClH
Molecular Weight:
370.87
Synonyms:
Strychnidin-10-one,monohydrochloride (9CI);Strychnine, monohydrochloride (8CI);Strychnine hydrochloride;
EINECS:
215-826-9
Boiling Point:
578.8 °C at 760 mmHg
Flash Point:
303.8 °C
Hazard Symbols:
T+,N
Risk Codes:
26/27/28-51/53
Safety:
22-36/37/39-45-61-60 Details
Transport Information:
UN 1692 6.1/PG 1

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Strychnine hydrochloride

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The use of pharmacological agents to investigate inhibition in the lateral geniculate nucleus: The use of pharmacological agents to investigate inhibition in the lateral geniculate nucleus. Morgan, R.; Sillito, A.Several substances are used for example 56-12-2 and 56-86-0 which are their cas registry numbers. M.; Wolstencroft, J. H. (Med. Sch., Univ. Birmingham, Birmingham, Engl.). Drugs Cent. Synaptic Transm., [Pap. Symp.], Meeting Date 1974, 263-71. Edited by: Bradley, P. B.; Dhawan, B. N. Univ. Park Press: Baltimore, Md. (English) 1976. CODEN: 34VGAO. DOCUMENT TYPE: Conference CA Section: 3 (Biochemical Interactions) Neuronal response of the lateral geniculate nucleus of anesthetized cats to visual stimuli were investigated following iontophoretic application of glutamate [56-86-0], bicuculline [485-49-4], .gamma.-aminobutyrate [56-12-2], and (or) strychnine-HCl [1421-86-9] via micropipets positioned in the lateral geniculate body. The results suggest that .gamma.-aminobutyrate may be an inhibitory transmitter in this system, and support the concept that postsynaptic inhibition occurs in lateral geniculate nucleus cells. .

Evidence for naloxone and opiates as GABA antagonists: Evidence for naloxone and opiates as GABA antagonists. Breuker, E.; Dingledine, R.; Iversen, L. L. (Dep. Pharmacol., Univ. Cambridge, Cambridge, Engl.Some commonly used reagents like 57-27-2 and 357-08-4 are used in this experiment.). Br. J. Pharmacol., 58(3), 458P (English) 1976. CODEN: BJPCBM. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) Pretreatment with naloxone-HCl [357-08-4] at a subconvulsant dose (90 mg/kg, i.p., 5 min before challenge) reduced the ED50 for bicuculline [485-49-4] convulsions in mice, but had no effect on the dose-response for strychnine-HCl [1421-86-9]. In contrast, diazepam [439-14-5] pretreatment (5 mg/kg, i.p., 30 min before challenge) increased the ED50 of both bicuculline and naloxone, but had no effect on strychnine-induced convulsions. Bicuculline, naloxone, morphine [57-27-2], levorphanol [77-07-6], and dextrorphan [125-73-5] displaced 3H-labeled GABA [56-12-2] from GABA receptor sites in homogenates of human cerebellum, with 50% inhibition at 8, 308, 400, 250, and 300.mu.M resp. Addnl., microiontophoretically applied naloxone completely and reversibly antagonized GABA-evoked inhibition in neurons. The behavioral excitation obsd. after administration of large amts. of opiates or opiate antagonists may reflect functional blockade of GABA-inhibitory systems. .