Detail of "14255-87-9"

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The effect of route of administration on the anthelmintic efficacy of benzimidazole anthelmintics in sheep infected with strains of Haemonchus contortus and Trichostrongylus colubriformis resistant or susceptible to thiabendazole

The effect of route of administration on the anthelmintic efficacy of benzimidazole anthelmintics in sheep infected with strains of Haemonchus contortus and Trichostrongylus colubriformis resistant or susceptible to thiabendazole. Kelly, J. D.; Hall, C. A.; Whitlock, H. V.; Thompson, H. G.; Campbell, N. J.; Martin, I. C. A. (Dep. Vet. Pathol., Univ. Sydney, Sydney, Aust.). Res. Vet. Sci., 22(2), 161-8 (English) 1977. CODEN: RVTSA9. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) Observations of erratic anthelmintic activity of fenbendazole [43210-67-9] against known standardized thiabendazole [148-79-8]-resistant strains of H. contortus and T. colubriformis in sheep were investigated. Fenbendazole at a dose rate of 10 mg/kg was administered by oral, intra-ruminal or intraabomasal routes, and was most effective against both resistant strains following intra-ruminal administratton. In addn. thiabendazole, oxibendazole [20559-55-1], fenbendazole, parbendazole [14255-87-9] and mebendazole [31431-39-7] plus 2 unrelated compds., levamisole-HCl [16595-80-5] and morantel tartrate [26155-31-7], were used at 1 and a half times their suggested or recommended therapeutic dose rate against thiabendazole-resistant strains of H. contorus and T. colubriformis in sheep; each drug being administered by the intra-ruminal or intra-abomasal routes. Fenbendazole was more effective against both strains following intra-ruminal administration. Parbendazole was more effective against the resistant strain of T. colubriformis following intra-ruminal administration. At the dose rate chosen for the other benzimidazoles used against these resistant strains, there was no difference in anthelmintic efficacy due to route of administration. Levamisole was highly effective against both resistant strains, irresp. of the route of administration. In the groups treated with morantel tartrate, the results obtained were difficult to interpret due to mortalities and a highly variable response in the surviving sheep. Fenbendazole, thiabendazole and mebendazole when used at their suggested or recommended therapeutic dose rate in sheep, were highly effective against known thiabendazole-susceptible strains of H. contortus and T. colubriformis following both intra-ruminal or intra-abomasal administration.

Embryotoxic and antimitotic properties of benzimidazole compounds

Embryotoxic and antimitotic properties of benzimidazole compounds. Delatour, P.; Richard, Y. (Lab. Toxicol. Virol., Ec. Natl. Vet. Lyon, Lyons, Fr.). Therapie, 31(4), 505-15 (French) 1976. CODEN: THERAP.In this article, certain chemicals are used. Some of their cas registry numbers are 22769-68-2 and 53716-50-0 DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) Of the 24 benzimidazole I derivs. studied, the 5- and 2-N-benzimidazolylcarbamates showed the greatest embryotoxicity in rats. Carbendazime [10605-21-7] was among the most toxic, being 100% embryolethal with maternal administration of 2 .times. 10-4 M/kg, orally, and producing anomalies in all embryos at 1 .times. 10-4 M/kg. Both in vivo and in vitro inhibition of cell proliferation was absd. An increase in the mitotic index of various cell cultures occurred. This was due to mitotic abnormalities (stathmometaphase) and picnotic nuclei. Multinuclear and multilobular cells along with giant polyploid nuclei were also seen. In mice with Ehrlich carcinoma parbendazole [14255-87-9], mebendazole [31431-39-7], and cambendazole [26097-80-3] inhibited tumor growth and increased survival time. Structure-activity relationships are discussed. .