Detail of "14277-97-5"

CAS Number:
14277-97-5
Name:
3-Pyrrolidineaceticacid, 2-carboxy-4-[(1Z,3E,5R)-5-carboxy-1-methyl-1,3-hexadien-1-yl]-,(2S,3S,4S)-
Molecular Structure:
Formula:
C15H21 N O6
Molecular Weight:
311.37
Synonyms:
3-Pyrrolidineaceticacid, 2-carboxy-4-(5-carboxy-1-methyl-1,3-hexadienyl)-, [2S-[2a,3b,4b(1Z,3E,5S*)]]-; 3-Pyrrolidineacetic acid,2-carboxy-4-[(1Z,3E,5R)-5-carboxy-1-methyl-1,3-hexadienyl]-, (2S,3S,4S)- (9CI);Domoic acid (6CI,7CI); (-)-Domoic acid; L-Domoic acid; NSC 288031
Density:
1.273 g/cm³
Melting Point:
228ºC
Boiling Point:
607.2 °C at 760 mmHg
Flash Point:
321 °C
Solubility:
methanol: 0.6 mg/mL，8mg/ml soluble in water.
Appearance:
White to off-white solid.
Hazard Symbols:
Xn
Risk Codes:
20/21/22
Safety:
A poison by intraperitoneal route. When heated to decomposition it emits toxic vapors of NO_x. Details

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DOMOIC ACID

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Address:18F, Raffles City, No.268 Xizang Road Central,

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Supplier:DIAGCHEM [ Canada]

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Tel:(902) 566-9116

Address:16 McCarville Street West Royalty Industrial Park Charlottetown, PE C1E 2A6

Supplier:BioVectra Inc. [ Canada]

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Tel:(866) 883-2872, ext. 6248

Address:Charlottetown, PE

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Insecticidal and neuromuscular activities of domoic acid and its related compounds: Insecticidal and neuromuscular activities of domoic acid and its related compounds. Maeda, Mitsuru; Kodama, Tohru; Tanaka, Takaharu; Ohfune, Yasufumi; Nomoto, Kyosuke; Nishimura, Keiichiro; Fujita, Toshio (Cent. Res. Inst., Suntory Ltd., Osaka 618, Japan). Nippon Noyaku Gakkaishi, 9(1), 27-32 (English) 1984. CODEN: NNGADV. ISSN: 0385-1559. DOCUMENT TYPE: Journal CA Section: 5 (Agrochemical Bioregulators) Domoic acid (I) [14277-97-5], isolated from a seaweed, had high insecticidal activity against cockroaches and houseflies. I was effective against the American cockroach at 0.8 mg/g (s.c.) and also induced significant contraction of the hindgut excised from the insect. The site of action may be the neuromuscular junction, similar to that of a-kainic acid [487-79-6]. Structure-activity relationships of kainic acids, and their N-alkyl and other derivs. were also discussed.

Acromelic acid, a novel excitatory amino acid from a poisonous mushroom: effects on the crayfish neuromuscular junction: Acromelic acid, a novel excitatory amino acid from a poisonous mushroom: effects on the crayfish neuromuscular junction. Shinozaki, H.; Ishida, M.; Okamoto, T. (Tokyo Metrop. Inst. Med. Sci., Tokyo 113, Japan). Brain Res., 399(2), 395-8 (English) 1986. CODEN: BRREAP. ISSN: 0006-8993. DOCUMENT TYPE: Journal CA Section: 4 (Toxicology) A novel amino acid, acromelic acid A [86630-09-3], which is one of the kainoids isolated from the poisonous mushroom Clitocybe acromelalga markedly depolarizes the crayfish opener muscle fiber in a dose-dependent manner, its potency being much greater than that of kainoids such as kainic acid [487-79-6] or domoic acid [14277-97-5]. Moreover, acromelic acid markedly potentiates the glutamate [56-86-0] response, in spite of the fact that it reduces the quisqualate [52809-07-1] response in a dose-dependent manner. The amplitude of excitatory junctional potentials was slightly reduced by acromelic acid.