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143-57-7

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Basic Information
CAS No.: 143-57-7
Name: PROTOVERATRINE A
Molecular Structure:
Molecular Structure of 143-57-7 (PROTOVERATRINE A)
Formula: C41H63 N O14
Molecular Weight: 793.95
Synonyms: Cevane-3,4,6,7,14,15,16,20-octol,4,9-epoxy-, 6,7-diacetate 3-(2-hydroxy-2-methylbutanoate)15-(2-methylbutanoate), [3b(S),4a,6a,7a,15a(R),16b]-; Cevane-3b,4b,6a,7a,14,15a,16b,20-octol, 4,9-epoxy-,6,7-diacetate 3-((+)-2-hydroxy-2-methylbutyrate) 15-((-)-2-methylbutyrate)(8CI); Protoverine, 6,7-diacetate 3-(2-hydroxy-2-methylbutyrate)15-(2-methylbutyrate) (6CI);2H-4,16a-Epoxybenzo[7,8]fluoreno[2,1-b]quinolizine,cevane-3,4,6,7,14,15,16,20-octol deriv.; NSC 23865; NSC 7526; Protalba;Protoveratrin; Protoveratrine; Protoveratrine A; Protoverine3-[(+)-(2S)-2-hydroxy-2-methylbutyrate] 6,7-diacetate15-[(-)-(2R)-2-methylbutyrate]
EINECS: 205-602-9
Density: 1.36 g/cm3
Melting Point: 267-269°C
Boiling Point: 810.6 °C at 760 mmHg
Flash Point: 444 °C
Hazard Symbols: VeryT+
Risk Codes: 26/27/28
Safety: 22-36/37/39-45
Transport Information: UN 1544 6
PSA: 218.82000
LogP: 1.54510
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Chemistry

MF: C41H63NO14
MW: 793.94
EINECS: 205-602-9
PROTOVERATRINE A,it's melting point is about 267-269°C.
Following is the molecular structure about it:

Uses

about Protoveratrine: Mixtures of closely related hypotensive alkaloids from Veratrum album (Liliaceae). They have been used in the treatment of hypertension but have largely been replaced by drugs with fewer adverse effects.

Toxicity Data With Reference

RTECS  FL5750100

1.   

orl-rat LD50:5 mg/kg

   AEPPAE    Naunyn-Schmiedebergs Archiv fuer Experimentelle Pathologie und Pharmakologie. 189 (1938),397.
2.   

scu-rat LD50:480 μg/kg

   APFRAD    Annales Pharmaceutiques Francaises. 14 (1956),783.
3.   

ipr-mus LD50:370 μg/kg

   PSEBAA    Proceedings of the Society for Experimental Biology and Medicine. 76 (1951),847.
4.   

scu-mus LD50:290 μg/kg

   JPETAB    Journal of Pharmacology and Experimental Therapeutics. 113 (1955),89.
5.   

ivn-mus LD50:31 μg/kg

   CKFRAY    Ceskoslovenska Farmacie. 10 (1961),413.
6.   

scu-dog LDLo:500 μg/kg

   AEXPBL    Archiv fuer Experimentelle Pathologie und Pharmakologie. 29 (1892),440.
7.   

scu-cat LDLo:500 μg/kg

   AEXPBL    Archiv fuer Experimentelle Pathologie und Pharmakologie. 29 (1892),440.
8.   

scu-rbt LDLo:250 μg/kg

   APFRAD    Annales Pharmaceutiques Francaises. 14 (1956),783.
9.   

ivn-rbt LDLo:50 μg/kg

   AEXPBL    Archiv fuer Experimentelle Pathologie und Pharmakologie. 29 (1892),440.
10.   

scu-frg LD50:4500 μg/kg

   

AEPPAE    Naunyn-Schmiedebergs Archiv fuer Experimentelle Pathologie und Pharmakologie. 189

Safety Profile

Safety Information about PROTOVERATRINE A:
Hazard Codes : T+
Risk Statements  26/27/28
Safety Statements  22-36/37/39-45
RIDADR  UN 1544 6.1/PG 1

Poison by ingestion, subcutaneous, intraperitoneal, and intravenous routes. When heated to decomposition it emits toxic fumes of NOx.
Protoveratrine is found to produce a striking fall in blood pressure in both essential and renal hypertension after intravenous administration.