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Detail of "143-67-9"

  • CAS Number:
  • 143-67-9
  • Name:

  • Vinblastine sulfate

  • Molecular Structure:
  • Formula:
  • C46H58N4O9
  • Molecular Weight:
  • 810.9741 .
  • Synonyms:
  • Alkaban-AQ;Exal;VLBmonosulfate;Velban;Velbe;Velsar;Vincaleukoblastine derivative;vincaleukoblastine, (2'beta)-;(2'beta)-Vincaleukoblastine;Vincaleukoblastine sulfate (1:1) (salt);Vinblastine 5;Rozevin sulfate;
  • EINECS:
  • 205-606-0
  • Density:
  • 1.37 g/cm3
  • Solubility:
  • water: 10 mg/mL
  • Appearance:
  • crystalline solid
  • Hazard Symbols:
  • HarmfulXn,ToxicT
  • Risk Codes:
  • 22-37/38-41-61-36/37/38-63-23/24/25
  • Safety:
  • 26-36/39-53-45-37/39-36/37/39 Details
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CAS No.143-67-9 Vinblastine sulfateCompetitive Product

TOXICITY: SAFETY: Production: Others: Vinblastine Sulfate PCM-CCH-003-020 – 20mg PCM-CCH-003-1000 – 1g CAS: 143-67-9 Marker For: Cathranthus. Roseus L. Molecular Formula C46H60N4O13S

Supplier:Phytomarker Ltd. [ China (Mainland)]

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CAS No.143-67-9 Vinblastine sulfate

Assay:≥95%  Appearance:powder or cr...  Package:10mg,20mg,1g...Storage:-20degree

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CAS No.143-67-9 Vinblastine sulfate

Assay:≥98%HPLC  Package:20mg;50mg;10...Storage:Store in dry...  Application:Analytical S...

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  Package:46 kg/vacuum...Storage:store at RT  Transportation:by sea/air  Application:Vinblastine

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CAS No.143-67-9 Vinblastine sulfate

Product Name: Vinblastine Sulfate Molecular Formula: C46H60N4O13S Molecular Weight: 909.05 CAS No.: 143-67-9 Specification: Vinblastine Sulfate: 99% Appearance: White crystalline fine powder Packing: Packed in paper-drums and two plastic-bags inside or as per your requirem

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Assay:98%

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CAS No.143-67-9 Vinblastine sulfate

Name 1,2-Dimethyl-3-hydroxy-4-pyridone Synonyms 3-Hydroxy-1,2-dimethyl-4(1H)pyridinone; Deferiprone Molecular Formula C7H9NO2 Molecular Weight 139.15 CAS Registry Number 30652-11-0 Properties Melting point 271-273 oC Water solubility soluble in hot w

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CAS No.143-67-9 Vinblastine sulfate

  Appearance:White to lig...

CBNumber: CB7407655 Chemical Name: Vinblastine sulfate Molecular Formula: C46H60N4O13S Formula Weight: 909.05 CAS No.: 143-67-9 MOL File: Mol file Melting Point: 267℃ Optical Rotation: -21.7°(c=2, CH3OH 21℃)

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CAS No.143-67-9 Vinblastine sulfate

Product Name: Vinblastine Sulfate Standard: USP28 CAS No: 143-67-9 EC No: 205-6-6-0 Molecular Formula: C46H58N4O9?H2SO4 Molecular Weight: 909.06 Acidity or Alkalinity: PH3.5-5.0 Assay: 95.0% Specific Rotation: -21.7°(c=2, CH3OH 21℃) Melting Point: 267℃ Appearance: Whit

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CAS No.143-67-9 Vinblastine sulfate

Vinblastine Sulfate CAS No.: 143-67-9 Appearance: white or offwhite powder, odorless Assay: 95%-105%

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1.Name: 4-Amino-2-trifluoromethylbenzonitrile Alias: 5-Amino-2-cyanobenzotrifluoride (Molecular formula :) C8H5F3N2 (Molecular weight :) 186.13 CAS NO.: 654-70-6 Appearance: White or light yellow crystalline powder. Assay: 99.0% Use: Bicalutamide intermediates. Package: 2

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CAS No.143-67-9 Vinblastine sulfate

[Product type]:Active pharmaceutical ingredients [English name]:vinblastine sulfate [Molecular formula]: C46H58N4O9?H2SO4 [Molecular weight ]: 908.97 [ C A S ]:143-67-9 [Quality standard]:USP31 [ Character ]:White or crystal powder, odourlessness, turns yellow when meeti

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Viblastine Sulfate

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Reference

Vinblastine potentiates the secretagog action of dibutyryl cyclic AMP on the exocrine pancreas
Vinblastine potentiates the secretagog action of dibutyryl cyclic AMP on the exocrine pancreas. Stock, C.; Launay, J. F.; Grenier, J. F.; Bauduin, H. (Unite Rech. 61, INSERM, Strasbourg, Fr.). Biochem. Biophys. Res. Commun., 76(2), 217-23 (English) 1977. CODEN: BBRCA9. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) Section cross-reference(s): 13 The effects of vinblastine sulfate (I) [143-67-9] on both structure and function of the pancreatic acinar cell were examd. in vitro. I potentiated the secretagog effect of dibutyryl cyclic AMP [362-74-3] but failed to affect the spontaneous release of enzyzme. This potentiation was parallel to the disappearance of cellular microtubules and depended on the dose and the time of exposure to I. The potentiation was energy dependent; it was more obvious in Ca contg. medium than in absence of Ca. A damaging effect of I on acinar cells was ruled out. These findings suggest the participation of microtubules in the secretory cycle of the pancreatic acinar cell.
The effect of microtubular inhibitors on transport of
The effect of microtubular inhibitors on transport of .alpha.-aminoisobutyric acid. Inhibition of uphill transport without changes in transmembrane gradients of sodium, potassium, or hydrogen ions. Goldman, I. David; Fyfe, Mary Jo; Bowen, Donnell; Loftfield, Sharon; Schafer, James A. (Dep. Med., Med. Coll. Virginia, Richmond, Va., USA). Biochim. Biophys. Acta, 467(2), 185-91 (English) 1977. CODEN: BBACAQ. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) Section cross-reference(s): 13 Alterations in .alpha.-aminoisobutyric acid [62-57-7] transport induced by vinca alkaloids were correlated with electrochem. potential differences for Na+, K+, or H+ across the cell membrane. vincristine [57-22-7] decreased the transmembrane steady-state gradient for .alpha.-aminoisobutyric acid by 13% or 18%. Vinblastine sulfate [143-67-9] decreased this gradient by 14.5%. There was no concurrent change in the chem. gradients for Na+, K+, or H+ across the cell membrane. A small, 4.08%, increase in the Cl- distribution ratio would not account for the much larger change in .alpha.-aminoisobutyric acid gradients on the basis of a decrease in the electrochem. potential for intracellular Na+. Thus, the decrease in the .alpha.-aminoisobutyric acid gradient across the Ehrlich ascites tumor cell membrane induced by vinca alkaloids cannot be attributed to a fall in the transmembrane electrochem. potential differences for Na+, K+, or H+. The data suggest a role for cellularr microtubules in the uphill transport of .alpha.-aminoisobutyric acid in this cell system.
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