Detail of "143558-00-3"

Reference

Extended duration of action of rocuronium in postpartum patients

Extended duration of action of rocuronium in postpartum patients. Puhringer, F. K.; Sparr, H. J.; Mitterschiffthaler, G.; Agoston, S.; Benzer, A. (Dep. Anaesthesia, Univ. Innsbruck, Innsbruck, Austria). Anesthesia & Analgesia (Baltimore), 84(2), 352-354 (English) 1997 Williams & Wilkins. CODEN: AACRAT. ISSN: 0003-2999. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) We studied the time course of action of a single bolus of 600 mg/kg rocuronium given during anesthesia with propofol, fentanyl, and nitrous oxide was studied in 12 nonpregnant and 12 postpartum patients. Neuromuscular effects were quantified by recording the indirectly evoked twitch response of the adductor pollicis muscle after ulnar nerve stimulation. In all patients, the trachea was intubated 60 s after administration of rocuronium. Onset time was similar in both groups (nonpregnant: 91 ± 28 s vs. postpartum: 95 ± 30 s), with the time to 25% twitch recovery being significantly longer (P < 0.001) in the postpartum patients (31.1 ± 3.6 min) compared with the nonpregnant group (24.9 ± 4.0 min). The time required for recovery from 25% to 75% of the control twitch response after reversal with neostigmine and atropine was significantly longer (P = 0.003) in postpartum (4.8 ± 0.9 min) than in nonpregnant patients (3.2 ± 0.6 min). These data suggest that pregnancy-induced changes result in prolonged effects of rocuronium in postpartum patients.Except for chemicals metioned above, 143558-00-3 is also used. .

Effect of cimetidine pretreatment on rocuronium-induced neuromuscular block

Effect of cimetidine pretreatment on rocuronium-induced neuromuscular block. Latorre, F.; de Almeida, M. C. S.; Stanek, A.; Weiler, N.; Kleemann, P. P. (Klinik Anaesthesiologie, Johannes Gutenberg-Universitaet, Mainz D-55101, Germany).In this article, certain chemicals are used. Some of their cas registry numbers are 143558-00-3 and 51481-61-9 Anaesthesist, 45(10), 900-902 (German) 1996 Springer. CODEN: ANATAE. ISSN: 0003-2417. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) To study the influence of a single i.v. dose of cimetidine on the neuromuscular effects of rocuronium, patients were given 400 mg cimetidine i.v. before anesthesia. Cimetidine did not alter the recovery from rocuronium-induced neuromuscular block. As a direct effect of cimetidine on the neuromuscular junction was not confirmed, it was suggested that cimetidine can be given as premedication without a risk of prolonged rocuronium block. .