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| CAS No.: | 144-80-9 |
|---|---|
| Name: | Sulfacetamide |
| Article Data: | 28 |
| Molecular Structure: | |
|
|
|
| Formula: | C8H10N2O3S |
| Molecular Weight: | 214.245 |
| Synonyms: | Acetamide,N-sulfanilyl- (7CI,8CI);4-(Acetylaminosulfonyl)aniline;Acetocid;Acetosulfamin;Acetosulfamine;Albamine;Albucid;Alesten;Formosulfacetamide;N-(4-Aminobenzenesulfonyl)acetamide;N-(p-Aminophenylsulfonyl)acetamide;N-Acetylsulfanilamide;N-Sulfanilylacetamide;N-[(4-Aminophenyl)sulfonyl]acetamide;N1-Acetylsulfanilamide;NSC 63871;N'-Acetylsulfanilamide;Ocusol;Region;Steramide;Sulamyd;Sulfacet;Sulfacetimide;Sulfacyl;Sulphacetamide;Sulphasil;Urosulfon;p-Aminobenzenesulfonacetamide; |
| EINECS: | 205-640-6 |
| Density: | 1.373 g/cm3 |
| Melting Point: | 182-184 °C |
| Boiling Point: | 71℃-76℃/30mmHg |
| Flash Point: | 107.073°C |
| Solubility: | <0.01 g/100 mL at 16 °C in water |
| Appearance: | white crystalline powder |
| Hazard Symbols: |
 Xi
|
| Risk Codes: | 20/21/22-36/37/38 |
| Safety: | 22-24/25-36-26 |
| Transport Information: | UN 3249 |
| PSA: | 97.64000 |
| LogP: | 2.14650 |
- 144851-82-1METHYL2-AMINO-3-FLUOROBENZOATE
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- 361456-36-2METHYL (R)-(+)-ISOCYANATO-3-PHENYLPROPI&
- 5156-58-1N-(1-Benzyl-4-pipperidinyl)-N-phenylpropanamide HCl
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- 50288-62-5threo-Phenyl-2-piperidyl acetamide
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| Conditions | Yield |
|---|---|
| With sulfuric acid at 30 - 40℃; for 0.5h; Product distribution; Mechanism; other carboxylic acids; | 86% |
| With sulfuric acid at 30 - 40℃; for 0.5h; | 86% |
| With 1,1'-carbonyldiimidazole In tetrahydrofuran |
- 108-24-7
acetic anhydride
- 63-74-1
sulfanilamide
A
- 5626-90-4
N-acetyl-4-(acetamido)benzenesulfonamide
B
- 144-80-9
sulphaacetamide
| Conditions | Yield |
|---|---|
| With sodium hydroxide In water at 75 - 85℃; for 0.25h; Acylation; | A 13% B 69% |
| Conditions | Yield |
|---|---|
| With sodium hydroxide for 2h; Reflux; | 30% |
| With sodium hydroxide | |
| With potassium hydroxide |
| Conditions | Yield |
|---|---|
| With sodium hydroxide |
- 50910-45-7
N-ethoxycarbonyl-sulfanilic acid acetylamide
- 144-80-9
sulphaacetamide
| Conditions | Yield |
|---|---|
| With sodium hydroxide |
| Conditions | Yield |
|---|---|
| With phosphoric acid |
- 847507-38-4
N-benzyloxycarbonyl-sulfanilic acid acetylamide
- 144-80-9
sulphaacetamide
| Conditions | Yield |
|---|---|
| With sodium hydroxide | |
| With ethanol; palladium Hydrogenation; | |
| With alkaline solution; palladium Hydrogenation; |
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Chemistry
MF: C8H10N2O3S
MW: 214.24
EINECS: 205-640-6
Density: 1.373 g/cm3
Storage temp: 0-6°C
Melting Point: 182-184 °C
Product Categories: API intermediates
Water Solubility: <0.01 g/100 mL at 16 ºC
Appearance: white crystalline powder Visual appearance of the given substance.
Stability: Stable. Incompatible with strong oxidizing agents, strong bases, strong reducing agents, strong acids.
Synonyms: AKOS BBB/023 ; LABOTEST-BB LT00053160 ; A-500 ; Acetamide, N-[(4-aminophenyl)sulfonyl]- ; Acetamide, N-sulfanilyl- ; Acetocid ; Acetosulfamin ; Acetosulfamine
Following is the molecular structure of N-sulfanilylacetamide (144-80-9):
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Uses
N-sulfanilylacetamide (144-80-9) is used as a sulfonamide antibiotic. It may also have anti-inflammatory properties .
Production
Reactivity Profile: N-sulfanilylacetamide (144-80-9) is an amide. Organic amides/imides react with azo and diazo compounds to generate toxic gases. Flammable gases are formed by the reaction of organic amides/imides with strong reducing agents. Amides are very weak bases (weaker than water). Imides are less basic yet and in fact react with strong bases to form salts. That is, they can react as acids. Mixing amides with dehydrating agents such as P2O5 or SOCl2 generates the corresponding nitrile. The combustion of these compounds generate mixed oxides of nitrogen (NOx).
Toxicity Data With Reference
| 1. | sln-nsc 250 mg/L | MUREAV Mutation Research. 167 (1986),35. | ||
| 2. | sln-smc 2 g/L | EVHPAZ EHP, Environmental Health Perspectives. Subseries of DHEW Publications. 31 (1979),97. | ||
| 3. | ivn-rat LD50:6600 mg/kg | AEPPAE Naunyn-Schmiedebergs Archiv fuer Experimentelle Pathologie und Pharmakologie. 211 (1950),367. | ||
| 4. | orl-mus LD50:16,500 mg/kg | JOURAA Journal of Urology. 47 (1942),183. | ||
| 5. | orl-dog LDLo:8 g/kg | JOURAA Journal of Urology. 47 (1942),183. | ||
| 6. | orl-rbt LDLo:5 g/kg | JOURAA Journal of Urology. 47 (1942),183. |
Consensus Reports
Reported in EPA TSCA Inventory. EPA Genetic Toxicology Program.
Safety Profile
Mildly toxic by ingestion and intravenous routes. An experimental teratogen. Mutation data reported. When heated to decomposition it emits very toxic fumes of NOx and SOx.
Safety Information of N-sulfanilylacetamide (144-80-9):
Hazard Codes: Xi
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Risk Statements: 20/21/22-36/37/38
20/21/22: Harmful by inhalation, in contact with skin and if swallowed
36/37/38: Irritating to eyes, respiratory system and skin
Safety Statements: 22-24/25-36-26
22: Do not breathe dust
24/25: Avoid contact with skin and eyes
36: Wear suitable protective clothing
26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
RIDADR: 3249
WGK Germany: 2
RTECS: AC8450000
HazardClass: 6.1(b)
PackingGroup: III
Specification
Handling and Storage of N-sulfanilylacetamide (144-80-9):
Storage: Keep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.
Handling: All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.